Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Huang, H.M.; Zhang, H.; Xu, H.; Gibson, G.E.
    Inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation (2003), Biochim. Biophys. Acta, 1637, 119-126.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.105 2-oxo-3-methyl-n-valeric acid inhibition of the 2-oxoglutarate dehydrogenase enzyme complex in vivo and in situ, after 40 min 25% inhibition at 10 mM, 46% at 20 mM, after 80 min 58% inhibition at 10 mM, 80% at 20 mM, inhibition does not affect the mitochondrial membrane potential Homo sapiens
1.2.1.105 additional information inhibition of the alpha-ketoglutarate dehydrogenase complex alters mitochondrial function and cellular calcium regulation Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.105 mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine Homo sapiens key step, probably rate-limiting, in the tricarboxylic acid cycle, physiologic function and regulation [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.1.105 additional information Homo sapiens reduced enzyme activity in vivo does not lead to the Ca2+ abnormalities observed in patients suffering brain disorders and abnormal mitochondrial function, or Alzheimer's disease, but the release of cytochrome c together with reduced enzyme activity activates other pathways including cell death cascades, enzyme inhibition alters Ca2+ homeostasis and increases cytosolic accumulation of cytochrome c ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.105 Homo sapiens
-
enzyme is part of the alpha-ketoglutarate dehydrogenase complex KGDHC
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.105 brain
-
Homo sapiens
-
1.2.1.105 fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine
-
Homo sapiens [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.1.105 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine key step, probably rate-limiting, in the tricarboxylic acid cycle, physiologic function and regulation Homo sapiens [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2
-
ir
1.2.1.105 additional information reduced enzyme activity in vivo does not lead to the Ca2+ abnormalities observed in patients suffering brain disorders and abnormal mitochondrial function, or Alzheimer's disease, but the release of cytochrome c together with reduced enzyme activity activates other pathways including cell death cascades, enzyme inhibition alters Ca2+ homeostasis and increases cytosolic accumulation of cytochrome c Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.105 More enzyme is part of the alpha-ketoglutarate dehydrogenase complex KGDHC Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.105 NAD+
-
Homo sapiens