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Literature summary extracted from

  • Lee, J.N.; Bae, S.H.; Paik, Y.K.
    Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene (2002), Biochim. Biophys. Acta, 1576, 148-156.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.21 additional information enzyme is induced when sterols are depleted both in vivo and in vitro Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.21 gene Dhcr7, chromosome mapping to 8q2.1, DNA and amino acid sequence determination and analysis of the full-length gene and the splicing variants Dhcr7-AS-1-5, gene structure, physical map, 5 alternative splicing variants Rattus norvegicus
1.3.1.21 gene Dhcr7, DNA and amino acid sequence determination and analysis, 1723 nucleotides, about 636 base pairs, gene structure, physical map, transcript half-life, alternative splicing variant 4 Rattus norvegicus
1.3.1.21 gene Dhcr7, DNA and amino acid sequence determination and analysis, gene structure, 1474 nucleotides, about 387 base pairs, physical map, transcript half-life, alternative splicing variant 1 Rattus norvegicus
1.3.1.21 gene Dhcr7, DNA and amino acid sequence determination and analysis, gene structure, 1595 nucleotides, about 508 base pairs, physical map, transcript half-life, alternative splicing variant 2 Rattus norvegicus
1.3.1.21 gene Dhcr7, DNA and amino acid sequence determination and analysis, no alternative splicing Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH Rattus norvegicus enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol cholesterol + NADP+
-
 ?
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH Homo sapiens enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol cholesterol + NADP+
-
 ?
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH Mus musculus enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol cholesterol + NADP+
-
 ?
1.3.1.21 additional information Mus musculus enzyme is regulated through tissue-specific transcription and differential alternative splicing ?
-
 ?
1.3.1.21 additional information Rattus norvegicus enzyme is regulated through tissue-specific transcription and differential alternative splicing, enzyme is induced when sterols are depleted both in vivo and in vitro ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.21 Homo sapiens Q9UBM7 enzyme Dhcr7, no additional isoforms, no alternative splicing
-
1.3.1.21 Mus musculus O88455 3 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7
-
1.3.1.21 Rattus norvegicus Q9E2H5 full-length gene, genomic DNA; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7, i.e. splicing variants Dhcr7-AS-1-5
-
1.3.1.21 Rattus norvegicus Q9Z2Z8 alternatively spliced variant 1, i.e. Dhcr7-AS-1; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7
-
1.3.1.21 Rattus norvegicus Q9Z2Z8 alternatively spliced variant 2, i.e. Dhcr7-AS-2; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7
-
1.3.1.21 Rattus norvegicus Q9Z2Z8 alternatively spliced variant 4, i.e. Dhcr7-AS-4; 5 isozymes of enzyme Dhcr7 through alternative splicing of gene Dhcr7
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.21 adrenal gland
-
 Rattus norvegicus
-
1.3.1.21 brain
-
 Rattus norvegicus
-
1.3.1.21 brain mainly expressed in Rattus norvegicus
-
1.3.1.21 Hep-G2 cell
-
 Homo sapiens
-
1.3.1.21 intestine
-
 Rattus norvegicus
-
1.3.1.21 kidney
-
 Rattus norvegicus
-
1.3.1.21 kidney low expression level Rattus norvegicus
-
1.3.1.21 L-929 cell
-
 Mus musculus
-
1.3.1.21 liver
-
 Rattus norvegicus
-
1.3.1.21 liver mainly expressed in Rattus norvegicus
-
1.3.1.21 lung
-
 Rattus norvegicus
-
1.3.1.21 additional information developmental/age-related expression pattern of Dhcr7-AS-1 Rattus norvegicus
-
1.3.1.21 additional information developmental/age-related expression pattern of Dhcr7-AS-2 Rattus norvegicus
-
1.3.1.21 additional information splicing variants Dhcr7-AS-1-5 are differentially expressed in the tissues Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol Rattus norvegicus cholesterol + NADP+
-
 ?
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol Homo sapiens cholesterol + NADP+
-
 ?
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH enzyme catalyzes the terminal step in cholesterol biosynthesis by reducing 7-dehydrocholesterol Mus musculus cholesterol + NADP+
-
 ?
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH i.e. 7-dehydrocholesterol Rattus norvegicus cholesterol + NADP+
-
 ?
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH i.e. 7-dehydrocholesterol Homo sapiens cholesterol + NADP+
-
 ?
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH i.e. 7-dehydrocholesterol Mus musculus cholesterol + NADP+
-
 ?
1.3.1.21 additional information enzyme is regulated through tissue-specific transcription and differential alternative splicing Mus musculus ?
-
 ?
1.3.1.21 additional information enzyme is regulated through tissue-specific transcription and differential alternative splicing, enzyme is induced when sterols are depleted both in vivo and in vitro Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.21 Dhcr7
-
 Rattus norvegicus
1.3.1.21 Dhcr7
-
 Homo sapiens
1.3.1.21 Dhcr7
-
 Mus musculus
1.3.1.21 Dhcr7-AS-1
-
 Rattus norvegicus
1.3.1.21 Dhcr7-AS-2
-
 Rattus norvegicus
1.3.1.21 Dhcr7-AS-4
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.21 NADPH
-
 Rattus norvegicus
1.3.1.21 NADPH
-
 Homo sapiens
1.3.1.21 NADPH
-
 Mus musculus