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Literature summary extracted from

  • Mardanyan, S.S.; Sharoyan, S.G.; Antonyan, A.A.; Lupidi, G.; Cristalli, G.
    Interaction of adenosine deaminase with inhibitors. Chemical modification by diethyl pyrocarbonate (2002), Biochemistry (Moscow), 67, 770-777.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.4 1-deazaadenosine
-
 Bos taurus
3.5.4.4 diethyl dicarbonate
-
 Bos taurus
3.5.4.4 erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine
-
 Bos taurus
3.5.4.4 erythro-9-(2-hydroxy-3-nonyl)-adenine
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.4 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.4 spleen
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.4 adenosine + H2O
-
 Bos taurus inosine + NH3
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.4.4 additional information
-
 additional information the adenine moiety of inhibitors does not bind to the histidine residues of the active site His238 Bos taurus
3.5.4.4 0.00007
-
 erythro-9-(2-hydroxy-3-nonyl)-adenine pH 7.1, 23°C, after preincubation with diethyl dicarbonate Bos taurus
3.5.4.4 0.00008
-
 erythro-9-(2-hydroxy-3-nonyl)-adenine pH 7.1, 23°C Bos taurus
3.5.4.4 0.00009
-
 diethyl dicarbonate pH 7.1, 23°C, in presence of 0.022 mM erythro-9-(2-hydroxy-3-nonyl)-adenine Bos taurus
3.5.4.4 0.00011
-
 erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine pH 7.1, 23°C, after preincubation with diethyl dicarbonate Bos taurus
3.5.4.4 0.00013
-
 diethyl dicarbonate pH 7.1, 23°C, in presence of 0.03 mM erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine Bos taurus
3.5.4.4 0.00014
-
 erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine pH 7.1, 23°C Bos taurus
3.5.4.4 0.007
-
 1-deazaadenosine pH 7.1, 23°C Bos taurus
3.5.4.4 0.0074
-
 1-deazaadenosine pH 7.1, 23°C, after preincubation with diethyl dicarbonate Bos taurus
3.5.4.4 0.01
-
 diethyl dicarbonate pH 7.1, 23°C, in presence of 0.008 mM 1-deazaadenosine Bos taurus