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Literature summary extracted from

  • Tarasev, M.; Ballou, D.P.
    Chemistry of the catalytic conversion of phthalate into its cis-dihydrodiol during the reaction of oxygen with the reduced form of phthalate dioxygenase (2005), Biochemistry, 44, 6197-6207.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.12.7 Iron one Rieske-type 2Fe-2S center and one mononuclear FeII center per monomer Burkholderia cepacia

Organism

EC Number Organism UniProt Comment Textmining
1.14.12.7 Burkholderia cepacia
-
-
-
1.14.12.7 Burkholderia cepacia DB01
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.14.12.7 phthalate + NADH + H+ + O2 = cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+ mechanism, product formation is tightly coupled to electron delivery, comparison of mechanisms of different dioxygenases Burkholderia cepacia
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.12.7 phthalate + NADH + H+ + O2
-
 Burkholderia cepacia cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+
-
 ?
1.14.12.7 phthalate + NADH + H+ + O2
-
 Burkholderia cepacia DB01 cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate + NAD+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.12.7 NADH
-
 Burkholderia cepacia