Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kapetanaki, S.M.; Chouchane, S.; Yu, S.; Zhao, X.; Magliozzo, R.S.; Schelvis, J.P.
    Mycobacterium tuberculosis KatG(S315T) catalase-peroxidase retains all active site properties for proper catalytic function (2005), Biochemistry, 44, 243-252.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.11.1.21 S315T most prevalent isonazid-resistant mutant, determination of Fe2+-binding/interaction structure, minimal alterations compared to the wild-type enzyme, mutant enzyme retains all active site properties for proper catalytic function Mycobacterium tuberculosis
1.11.1.21 S315T isoniazid-resistant, mutant catalase-peroxidase retains all active site properties for proper catalytic function Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.11.1.21 CO complexed with the enzyme, structure determination, binding kinetics Mycobacterium tuberculosis
1.11.1.21 Fe2+ wild-type and S315T mutant enzyme, determination of Fe2+-binding/interaction structure Mycobacterium tuberculosis
1.11.1.21 NO complexed with the enzyme, structure determination, binding kinetics Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.21 H2O2 Mycobacterium tuberculosis
-
O2 + H2O
-
?
1.11.1.21 isoniazid + H2O2 Mycobacterium tuberculosis activation of antituberculosis drug isonazid, catalytic mechanism ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.21 Mycobacterium tuberculosis
-
-
-
1.11.1.21 Mycobacterium tuberculosis
-
enzyme KatG is a bifunctional
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.11.1.21 2 H2O2 = O2 + 2 H2O catalytic mechanism Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.21 H2O2
-
Mycobacterium tuberculosis O2 + H2O
-
?
1.11.1.21 isoniazid + H2O2
-
Mycobacterium tuberculosis ?
-
?
1.11.1.21 isoniazid + H2O2 activation of antituberculosis drug isonazid, catalytic mechanism Mycobacterium tuberculosis ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.21 catalase-peroxidase
-
Mycobacterium tuberculosis
1.11.1.21 catalase-peroxidase bifunctional enzyme with activities of EC 1.11.1.6 and EC 1.11.1.7 Mycobacterium tuberculosis
1.11.1.21 KatG
-
Mycobacterium tuberculosis
1.11.1.21 KatG bifunctional enzyme with activities of EC 1.11.1.6 and EC 1.11.1.7 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.21 heme wild-type and S315T mutant enzyme, determination of Fe2+-binding/interaction structure Mycobacterium tuberculosis