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Literature summary extracted from

  • Balbo, P.B.; Patel, C.N.; Sell, K.G.; Adcock, R.S.; Neelakantan, S.; Crooks, P.A.; Oliveira, M.A.
    Spectrophotometric and steady-state kinetic analysis of the biosynthetic arginine decarboxylase of Yersinia pestis utilizing arginine analogues as inhibitors and alternative substrates (2003), Biochemistry, 42, 15189-15196.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.19 agmatine
-
 Yersinia pestis
4.1.1.19 D-Arg
-
 Yersinia pestis
4.1.1.19 guanidine
-
 Yersinia pestis
4.1.1.19 L-arginine methyl ester
-
 Yersinia pestis
4.1.1.19 L-arginineamide
-
 Yersinia pestis
4.1.1.19 L-argininic acid
-
 Yersinia pestis
4.1.1.19 L-canavanine
-
 Yersinia pestis
4.1.1.19 L-homoarginine
-
 Yersinia pestis
4.1.1.19 methylguanidine
-
 Yersinia pestis
4.1.1.19 N-benzylguanidine
-
 Yersinia pestis
4.1.1.19 n-propylguanidine
-
 Yersinia pestis
4.1.1.19 Ngamma-methyl-D-arginine
-
 Yersinia pestis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.19 0.163
-
 Ngamma-methyl-L-arginine pH 7.5, 37°C Yersinia pestis
4.1.1.19 0.2
-
 L-Arg pH 7.5, 37°C Yersinia pestis
4.1.1.19 0.233
-
 L-canavanine pH 7.5, 37°C Yersinia pestis
4.1.1.19 9.53
-
 L-N5-(iminoethyl)-ornithine pH 7.5, 37°C Yersinia pestis

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.19 Yersinia pestis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.19 L-arginine
-
 Yersinia pestis agmatine + CO2
-
 ?
4.1.1.19 L-canavanine
-
 Yersinia pestis N-(3-aminopropoxy)guanidine + CO2
-
 ?
4.1.1.19 L-N5-(iminoethyl)-ornithine
-
 Yersinia pestis N1-(2-iminoethyl)-butane-1,4-diamine + CO2
-
 ?
4.1.1.19 Ngamma-monomethyl-L-Arg
-
 Yersinia pestis N-(3-aminopropyl)-N'-methylguanidine + CO2
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.1.19 0.11
-
 L-canavanine pH 7.5, 37°C Yersinia pestis
4.1.1.19 0.419
-
 L-N5-(iminoethyl)-ornithine pH 7.5, 37°C Yersinia pestis
4.1.1.19 1.22
-
 Ngamma-methyl-L-arginine pH 7.5, 37°C Yersinia pestis
4.1.1.19 5.46
-
 L-Arg pH 7.5, 37°C Yersinia pestis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.19 0.0206
-
 D-Arg pH 7.5, 37°C Yersinia pestis
4.1.1.19 0.168
-
 NG-methyl-D-arginine pH 7.5, 37°C Yersinia pestis
4.1.1.19 0.189
-
 L-arginine methyl ester pH 7.5, 37°C Yersinia pestis
4.1.1.19 0.327
-
 L-argininic acid pH 7.5, 37°C Yersinia pestis
4.1.1.19 0.427
-
 L-canavanine pH 7.5, 37°C Yersinia pestis
4.1.1.19 0.897
-
 L-argininamide pH 7.5, 37°C Yersinia pestis
4.1.1.19 1.4
-
 N-benzylguanidine pH 7.5, 37°C Yersinia pestis
4.1.1.19 1.53
-
 L-homoarginine pH 7.5, 37°C Yersinia pestis
4.1.1.19 1.93
-
 n-propylguanidine pH 7.5, 37°C Yersinia pestis
4.1.1.19 2.77
-
 agmatine pH 7.5, 37°C Yersinia pestis
4.1.1.19 3.09
-
 methylguanidine pH 7.5, 37°C Yersinia pestis
4.1.1.19 3.39
-
 guanidine pH 7.5, 37°C Yersinia pestis