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Literature summary extracted from

  • Maser, E.; Volker, B.; Friebertshauser, J.
    11 beta-Hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase (2002), Biochemistry, 41, 2459-2465.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.146 cloning of cDNA Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 glycyrrhetinic acid
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.146 0.014
-
 cortisone 37°C, pH 7.4, Hill coefficient of 1.6 Homo sapiens
1.1.1.146 0.02
-
 dehydrocorticosterone 37°C, pH 7.4, Hill coefficient of 2.7 Homo sapiens
1.1.1.146 0.041
-
 cortisol 37°C, pH 7.4, Hill coefficient of 1.0, no cooperative kinetic Homo sapiens
1.1.1.146 0.043
-
 corticosterone 37°C, pH 7.4, Hill coefficient of 0.7 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.146 endoplasmic reticulum
-
 Homo sapiens 5783
-
1.1.1.146 membrane membrane bound Homo sapiens 16020
-
1.1.1.146 microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.146 32386
-
 2 * 32386, deduced from nucleotide sequence Homo sapiens
1.1.1.146 34000
-
 2 * 34000, SDS-PAGE Homo sapiens
1.1.1.146 67400
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+ Homo sapiens primarly a reductase in vivo cortisol + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.1.1.146 glycoprotein
-
 Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.146 solubilized microsomes, octyl-Sepharose, Mono Q-Sepharose, Red Sepharose A Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.146 91.36
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 r
1.1.1.146 cortisone + NADPH + H+ primarly a reductase in vivo Homo sapiens cortisol + NADP+
-
 r
1.1.1.146 dehydrocorticosterone + NADPH
-
 Homo sapiens corticosterone + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.146 dimer 2 * 34000, SDS-PAGE Homo sapiens
1.1.1.146 dimer 2 * 32386, deduced from nucleotide sequence Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.146 0.0000049
-
 glycyrrhetinic acid 37°C, pH 9.0, inhibition of cortisol oxidation Homo sapiens
1.1.1.146 0.000014
-
 glycyrrhetinic acid 37°C, pH 9.0, inhibition of cortisone reduction Homo sapiens