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Literature summary extracted from

  • Ramjeesingh, M.; Li, C.; Kogan, I.; Wang, Y.; Huan, L.J.; Bear, C.E.
    A monomer is the minimum functional unit required for channel and ATPase activity of the cystic fibrosis transmembrane conductance regulator (2001), Biochemistry, 40, 10700-10706.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.6.1.6 expression in Escherichia coli Homo sapiens
5.6.1.6 stable expressed in CHO cells and transiently transfected in Sf9 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.6.1.6 membrane
-
 Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
5.6.1.6 170000
-
 1 * 170000, CFTR exitsts as monomers and multimers, the monomer is the minimum functional unit required for channel and ATPase activity, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel Homo sapiens the enzyme normally functions as a phosphorylation-regulated chloriode channel on the apical surface of epithelial cells, and lack of this function is the primary cause for the fatal disease cystic fibrosis ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 additional information Homo sapiens the cystic fibrosis transmembrane conductance regulator normally functions as a phosphorylation-regulated chloride channel on the apical surface of epithelial cell, and lack of this function is the primary cause for the fatal disease cystic fibrosis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.6 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.6.1.6
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.6 ATP + H2O + closed Cl- channel
-
 Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 ATP + H2O + closed Cl- channel the enzyme normally functions as a phosphorylation-regulated chloriode channel on the apical surface of epithelial cells, and lack of this function is the primary cause for the fatal disease cystic fibrosis Homo sapiens ADP + phosphate + open Cl- channel
-
 ?
5.6.1.6 additional information the cystic fibrosis transmembrane conductance regulator normally functions as a phosphorylation-regulated chloride channel on the apical surface of epithelial cell, and lack of this function is the primary cause for the fatal disease cystic fibrosis Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
5.6.1.6 monomer 1 * 170000, CFTR exitsts as monomers and multimers, the monomer is the minimum functional unit required for channel and ATPase activity, SDS-PAGE Homo sapiens
5.6.1.6 More enzyme function does not require a multimeric complex for function, reconstituted monomers are sufficient to mediate regulated chloride conduction and ATPase activity Homo sapiens
5.6.1.6 multimer CFTR exitsts as monomers and multimers Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
5.6.1.6 CFTR
-
 Homo sapiens
5.6.1.6 cystic fibrosis transmembrane conductance regulator
-
 Homo sapiens