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Literature summary extracted from
- 5,10-methenyltetrahydrofolate cyclohydrolase, rat liver and chemically catalysed formation of 5-formyltetrahydrofolate (2003), Biochem. J., 374, 773-778.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.4.9 | additional information | - |
additional information | kinetics | Rattus norvegicus | |
| 3.5.4.9 | 0.009 | - |
10-formyltetrahydrofolate | pH 7.0, 23°C | Rattus norvegicus |  |
| 3.5.4.9 | 0.009 | - |
5,10-methenyltetrahydrofolate | pH 7.0, 23°C | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.9 | additional information | Rattus norvegicus | the determined amount of 5-formyltetrahydrofolate formation in the liver is low, possible role in one-carbon metabolism | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.9 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.4.9 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.5.4.9 | 0.0002 | - |
cyclohydrolase activity, rat liver, formation of 5-formyltetrahydrofolate | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.9 | 10-formyltetrahydrofolate | low activity in the liver | Rattus norvegicus | 5,10-methenyltetrahydrofolate + H2O | - |
? | |
| 3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Rattus norvegicus | 10-formyltetrahydrofolate | - |
r | |
| 3.5.4.9 | 5,10-methenyltetrahydrofolate + H2O | - |
Rattus norvegicus | 5-formyltetrahydrofolate | - |
r | |
| 3.5.4.9 | additional information | the determined amount of 5-formyltetrahydrofolate formation in the liver is low, possible role in one-carbon metabolism | Rattus norvegicus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.4.9 | 5,10-CH=H4 folate synthetase | - |
Rattus norvegicus |
| 3.5.4.9 | 5,10-methenyltetrahydrofolate cyclohydrolase | - |
Rattus norvegicus |
| 3.5.4.9 | 5,10-Methenyltetrahydrofolate synthetase | - |
Rattus norvegicus |
| 3.5.4.9 | More | 5,10-methenyltetrahydrofolate cyclohydrolase and 5,10-methenyltetrahydrofolate synthetase might be 2 different enzymes | Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.4.9 | 23 | - |
assay at | Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.4.9 | 7 | - |
assay at | Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.4.9 | 4 | 7 | 5-formyltetrahydrofolate formation | Rattus norvegicus |
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Release 2023.1 (January 2023)
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