EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.72 | 5,22-cholestedien-3beta-ol | desmosterol isomer, competitive inhibition | Homo sapiens | |
1.3.1.72 | 5,22-cholestedien-3beta-ol | desmosterol isomer, competitive inhibition | Rattus norvegicus | |
1.3.1.72 | brassicasterol | DELTA22-unsaturated phytosterol, competitive inhibition | Homo sapiens | |
1.3.1.72 | brassicasterol | DELTA22-unsaturated phytosterol, competitive inhibition | Rattus norvegicus | |
1.3.1.72 | ergosterol | DELTA22-unsaturated phytosterol, competitive inhibition | Homo sapiens | |
1.3.1.72 | ergosterol | DELTA22-unsaturated phytosterol, competitive inhibition | Rattus norvegicus | |
1.3.1.72 | additional information | inhibition mechanism of DELTA22-unsaturated phytosterols | Homo sapiens | |
1.3.1.72 | additional information | inhibition mechanism of DELTA22-unsaturated phytosterols | Rattus norvegicus | |
1.3.1.72 | stigmasterol | DELTA22-unsaturated phytosterol, competitive inhibition | Homo sapiens | |
1.3.1.72 | stigmasterol | DELTA22-unsaturated phytosterol, competitive inhibition | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.72 | 26.3 | - |
desmosterol | pH 7.6, 37°C | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.3.1.72 | membrane | bound | Homo sapiens | 16020 | - |
1.3.1.72 | membrane | bound | Rattus norvegicus | 16020 | - |
1.3.1.72 | microsome | - |
Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.72 | 5alpha-cholesta-7,24-dien-3beta-ol + NADPH | Homo sapiens | step in the biosynthesis of cholesterol from lanosterol | 5alpha-cholest-7-en-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | 5alpha-cholesta-7,24-dien-3beta-ol + NADPH | Rattus norvegicus | step in the biosynthesis of cholesterol from lanosterol | 5alpha-cholest-7-en-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | cholesta-5,7,24-trien-3beta-ol + NADPH | Homo sapiens | step in the biosynthesis of cholesterol from lanosterol | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | cholesta-5,7,24-trien-3beta-ol + NADPH | Rattus norvegicus | step in the biosynthesis of cholesterol from lanosterol | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | desmosterol + NADPH | Homo sapiens | step in the biosynthesis of cholesterol from lanosterol | cholesterol + NADP+ | - |
? | |
1.3.1.72 | desmosterol + NADPH | Rattus norvegicus | step in the biosynthesis of cholesterol from lanosterol | cholesterol + NADP+ | - |
? | |
1.3.1.72 | lanosterol + NADPH | Homo sapiens | step in the biosynthesis of cholesterol from lanosterol | 24-dihydrolanosterol + NADP+ | - |
? | |
1.3.1.72 | lanosterol + NADPH | Rattus norvegicus | step in the biosynthesis of cholesterol from lanosterol | 24-dihydrolanosterol + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.72 | Homo sapiens | - |
- |
- |
1.3.1.72 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.1.72 | Caco-2 cell | intestinal mucosa cells | Homo sapiens | - |
1.3.1.72 | HL-60 cell | promyelocytic cells | Homo sapiens | - |
1.3.1.72 | liver | - |
Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.72 | 5alpha-cholesta-7,24-dien-3beta-ol + NADPH | best substrate | Homo sapiens | 5alpha-cholest-7-en-3beta-ol + NADP+ | i.e.lathosterol | ? | |
1.3.1.72 | 5alpha-cholesta-7,24-dien-3beta-ol + NADPH | best substrate | Rattus norvegicus | 5alpha-cholest-7-en-3beta-ol + NADP+ | i.e.lathosterol | ? | |
1.3.1.72 | 5alpha-cholesta-7,24-dien-3beta-ol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Homo sapiens | 5alpha-cholest-7-en-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | 5alpha-cholesta-7,24-dien-3beta-ol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Rattus norvegicus | 5alpha-cholest-7-en-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | cholesta-5,7,24-trien-3beta-ol + NADPH | - |
Homo sapiens | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | cholesta-5,7,24-trien-3beta-ol + NADPH | - |
Rattus norvegicus | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | cholesta-5,7,24-trien-3beta-ol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Homo sapiens | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | cholesta-5,7,24-trien-3beta-ol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Rattus norvegicus | cholest-5,7-dien-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | desmosterol + NADPH | - |
Homo sapiens | cholesterol + NADP+ | - |
? | |
1.3.1.72 | desmosterol + NADPH | - |
Rattus norvegicus | cholesterol + NADP+ | - |
? | |
1.3.1.72 | desmosterol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Homo sapiens | cholesterol + NADP+ | - |
? | |
1.3.1.72 | desmosterol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Rattus norvegicus | cholesterol + NADP+ | - |
? | |
1.3.1.72 | lanosterol + NADPH | - |
Homo sapiens | 24-dihydrolanosterol + NADP+ | - |
? | |
1.3.1.72 | lanosterol + NADPH | - |
Rattus norvegicus | 24-dihydrolanosterol + NADP+ | - |
? | |
1.3.1.72 | lanosterol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Homo sapiens | 24-dihydrolanosterol + NADP+ | - |
? | |
1.3.1.72 | lanosterol + NADPH | step in the biosynthesis of cholesterol from lanosterol | Rattus norvegicus | 24-dihydrolanosterol + NADP+ | - |
? | |
1.3.1.72 | zymosterol + NADPH | - |
Homo sapiens | 5alpha-cholesta-8-en-3beta-ol + NADP+ | - |
? | |
1.3.1.72 | zymosterol + NADPH | - |
Rattus norvegicus | 5alpha-cholesta-8-en-3beta-ol + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.1.72 | desmosterol reductase | - |
Homo sapiens |
1.3.1.72 | desmosterol reductase | - |
Rattus norvegicus |
1.3.1.72 | lanosterol reductase | - |
Homo sapiens |
1.3.1.72 | lanosterol reductase | - |
Rattus norvegicus |
1.3.1.72 | sterol 24DELTA-reductase | - |
Homo sapiens |
1.3.1.72 | sterol 24DELTA-reductase | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.3.1.72 | 37 | - |
assay at | Homo sapiens |
1.3.1.72 | 37 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.3.1.72 | 7.6 | - |
assay at | Homo sapiens |
1.3.1.72 | 7.6 | - |
assay at | Rattus norvegicus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.72 | NADPH | - |
Homo sapiens | |
1.3.1.72 | NADPH | - |
Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.72 | 0.0033 | - |
5,22-cholestedien-3beta-ol | pH 7.6, 37°C | Rattus norvegicus | |
1.3.1.72 | 0.037 | - |
ergosterol | pH 7.6, 37°C | Rattus norvegicus | |
1.3.1.72 | 0.041 | - |
stigmasterol | pH 7.6, 37°C | Rattus norvegicus | |
1.3.1.72 | 0.043 | - |
brassicasterol | pH 7.6, 37°C | Rattus norvegicus |