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Literature summary extracted from

  • Herraiz, T.; Chaparro, C.
    Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors (2005), Biochem. Biophys. Res. Commun., 326, 378-386.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.4.3.4 medicine target for antidepressant and neuroprotective drugs Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 beta-carbolines competitive reversible and potent inhibitor Homo sapiens
1.4.3.4 harman
-
 Homo sapiens
1.4.3.4 additional information cigarette smoke is a potent inhibitor of MAO-A. Inhibition is partly reversible, competitive. beta-Carboline alkaloids from cigarette smoke acting as potent reversible inhibitors may contribute to the MAO reduced activity produced by tobacco smoke in smokers; cigarette smoke is a potent inhibitor of MAO-B. Inhibition is partly reversible, competitive. Veta-carboline alkaloids from cigarette smoke acting as potent reversible inhibitors may contribute to the MAO reduced activity produced by tobacco smoke in smokers Homo sapiens
1.4.3.4 norharman competitive reversible and potent inhibitor Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrial outer membrane
-
 Homo sapiens 5741
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.4 additional information Homo sapiens the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 30% lower activity of peripheral and brain MAO-A compared to smokers ?
-
 ?
1.4.3.4 additional information Homo sapiens the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 40% lower activity of peripheral and brain MAO-B compared to smokers ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 kynuramine + H2O + O2
-
 Homo sapiens 3-(2-aminophenyl)-3-oxopropanal + NH3 + H2O2
-
 ?
1.4.3.4 additional information the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 30% lower activity of peripheral and brain MAO-A compared to smokers Homo sapiens ?
-
 ?
1.4.3.4 additional information the enzyme is involved in brain and peripheral oxidative catabolism of neurotransmitters and xenobiotic amines, including neurotoxic amines. Smokers have a 40% lower activity of peripheral and brain MAO-B compared to smokers Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.4.3.4 MAO-A
-
 Homo sapiens
1.4.3.4 MAO-B
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.4.3.4 0.00005554
-
 harman pH 7.4, 37°C, monoamine oxidase A Homo sapiens
1.4.3.4 0.00112
-
 norharman pH 7.4, 37°C, monoamine oxidase B Homo sapiens
1.4.3.4 0.0012
-
 norharman pH 7.4, 37°C, monoamine oxidase A Homo sapiens