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Literature summary extracted from

  • Inoue, S.; Lin, S.L.; Inoue, Y.; Groves, D.R.; Thomson, R.J.; von Itzstein, M.; Pavlova, N.V.; Li, S.C.; Li, Y.T.
    A unique sialidase that cleaves the Neu5Gcalpha2->5-OglycolylNeu5Gc linkage: comparison of its specificity with that of three microbial sialidases toward four sialic acid dimers (2001), Biochem. Biophys. Res. Commun., 280, 104-109.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.18 Neu5Ac2en inhibits competitively the hydrolysis of KDNalpha-(2-8)-KDN Crassostrea virginica
3.2.1.18 sialyl-2en inhibits competitively the hydrolysis of Neu5Gcalpha-(2-5)-O-glycolylNeu5Gc Crassostrea virginica

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.18 Clostridium perfringens
-
-
-
3.2.1.18 Crassostrea virginica
-
 oyster
-
3.2.1.18 Paenarthrobacter ureafaciens
-
-
-
3.2.1.18 Vibrio cholerae serotype O1
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.1.18 partial Crassostrea virginica

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.18 hepatopancreas
-
 Crassostrea virginica
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.18 4-methylumbelliferyl-alpha-D-N-acetylneuraminic acid + H2O
-
 Crassostrea virginica 4-methylumbelliferol + alpha-D-N-acetylneuraminic acid
-
 ?
3.2.1.18 alpha-sialyllactose + H2O
-
 Clostridium perfringens sialic acid + lactose
-
 ?
3.2.1.18 alpha-sialyllactose + H2O
-
 Paenarthrobacter ureafaciens sialic acid + lactose
-
 ?
3.2.1.18 alpha-sialyllactose + H2O
-
 Vibrio cholerae serotype O1 sialic acid + lactose
-
 ?
3.2.1.18 additional information no activity with sialyl-alpha-(2-8)-sialic acid Clostridium perfringens ?
-
 ?
3.2.1.18 additional information no activity with sialyl-alpha-(2-8)-sialic acid Paenarthrobacter ureafaciens ?
-
 ?
3.2.1.18 additional information no activity with sialyl-alpha-(2-8)-sialic acid Vibrio cholerae serotype O1 ?
-
 ?
3.2.1.18 additional information the dimers Neu5Gcalpha-(2-8)-Neu5Ac and Neu5Gcalpha-(2-8)-Neu5Gc are poor substrates Crassostrea virginica ?
-
 ?
3.2.1.18 Neu5Gcalpha-(2-5)-O-glycolylNeu5Gc + H2O
-
 Clostridium perfringens 2 Neu5Gcalpha
-
 ?
3.2.1.18 Neu5Gcalpha-(2-5)-O-glycolylNeu5Gc + H2O
-
 Paenarthrobacter ureafaciens 2 Neu5Gcalpha
-
 ?
3.2.1.18 Neu5Gcalpha-(2-5)-O-glycolylNeu5Gc + H2O
-
 Vibrio cholerae serotype O1 2 Neu5Gcalpha
-
 ?
3.2.1.18 Neu5Gcalpha-(2-5)-O-glycolylNeu5Gc + H2O
-
 Crassostrea virginica 2 Neu5Gcalpha
-
 ?
3.2.1.18 Neu5Gcalpha-(2-8)-Neu5Ac + H2O preferred substrate Clostridium perfringens Neu5Gc + Neu5Ac
-
 ?
3.2.1.18 Neu5Gcalpha-(2-8)-Neu5Ac + H2O preferred substrate Paenarthrobacter ureafaciens Neu5Gc + Neu5Ac
-
 ?
3.2.1.18 Neu5Gcalpha-(2-8)-Neu5Ac + H2O preferred substrate Vibrio cholerae serotype O1 Neu5Gc + Neu5Ac
-
 ?
3.2.1.18 Neu5Gcalpha-(2-8)-Neu5Gc + H2O
-
 Vibrio cholerae serotype O1 Neu5Gc + Neu5Gc
-
 ?
3.2.1.18 Neu5Gcalpha-(2-8)-Neu5Gc + H2O low activity Clostridium perfringens Neu5Gc + Neu5Gc
-
 ?
3.2.1.18 Neu5Gcalpha-(2-8)-Neu5Gc + H2O low activity Paenarthrobacter ureafaciens Neu5Gc + Neu5Gc
-
 ?
3.2.1.18 polysialic acid + H2O preference for cleavage of polymers with (-5-O-glycolylNeu5Gc2-)-units, also cleaves polymers with (-8Neu5Acalpha2-)- and (-8Neu5Gcalpha2-)-units Crassostrea virginica sialic acid
-
 ?
3.2.1.18 sialyl-alpha-(2-8)-sialic acid + H2O
-
 Crassostrea virginica sialic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.18 sialidase
-
 Clostridium perfringens
3.2.1.18 sialidase
-
 Paenarthrobacter ureafaciens
3.2.1.18 sialidase
-
 Vibrio cholerae serotype O1
3.2.1.18 sialidase
-
 Crassostrea virginica

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.18 37
-
 assay at Clostridium perfringens
3.2.1.18 37
-
 assay at Paenarthrobacter ureafaciens
3.2.1.18 37
-
 assay at Vibrio cholerae serotype O1
3.2.1.18 37
-
 assay at Crassostrea virginica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.18 4.1
-
 assay at Crassostrea virginica
3.2.1.18 5.5
-
 assay at Clostridium perfringens
3.2.1.18 5.5
-
 assay at Paenarthrobacter ureafaciens
3.2.1.18 5.8
-
 assay at Vibrio cholerae serotype O1