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Literature summary extracted from

  • Cho, H.; Tai, H.H.
    Thiazolidinediones as a novel class of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors (2002), Arch. Biochem. Biophys., 405, 247-251.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.141 4-methoxybenzyl-2,4-thiazolidinedione
-
 Homo sapiens
1.1.1.141 4-methoxybenzylidene-2,4-thiazolidinedione
-
 Homo sapiens
1.1.1.141 5-[4-((1-methyl)-cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione
-
 Homo sapiens
1.1.1.141 5-[4-((1-methyl)-cyclohexylmethoxy)benzyl]-2,4-thiazolidenedione trivial name ciglitazone Homo sapiens
1.1.1.141 5-[4-(benzoxy)benzylidene]-2,4-thiazolidenedione
-
 Homo sapiens
1.1.1.141 5-[4-(cyclohexylbutoxy)benzylidene]-2,4-thiazolidenedione
-
 Homo sapiens
1.1.1.141 5-[4-(cyclohexylethoxy)benzylidene]-2,4-thiazolidenedione
-
 Homo sapiens
1.1.1.141 5-[4-(cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione
-
 Homo sapiens
1.1.1.141 5-[4-(cyclohexyloxy)benzylidene]-2,4-thiazolidenedione
-
 Homo sapiens
1.1.1.141 5-[4-(cyclohexylpropoxy)benzylidene]-2,4-thiazolidenedione
-
 Homo sapiens
1.1.1.141 ciglitazone
-
 Homo sapiens
1.1.1.141 rosiglitazone
-
 Homo sapiens
1.1.1.141 troglitazone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens
-
 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-PGDH
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.141 0.00009
-
 5-[4-(cyclohexylethoxy)benzylidene]-2,4-thiazolidenedione 37°C, pH 7.5 Homo sapiens
1.1.1.141 0.00011
-
 5-[4-(cyclohexylpropoxy)benzylidene]-2,4-thiazolidenedione 37°C, pH 7.5 Homo sapiens
1.1.1.141 0.00027
-
 5-[4-(cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione 37°C, pH 7.5 Homo sapiens
1.1.1.141 0.0006
-
 5-[4-((1-methyl)-cyclohexylmethoxy)benzylidene]-2,4-thiazolidenedione 37°C, pH 7.5 Homo sapiens
1.1.1.141 0.0009
-
 5-[4-(cyclohexyloxy)benzylidene]-2,4-thiazolidenedione 37°C, pH 7.5 Homo sapiens
1.1.1.141 0.0012
-
 5-[4-(benzoxy)benzylidene]-2,4-thiazolidenedione 37°C, pH 7.5 Homo sapiens
1.1.1.141 0.0022
-
 5-[4-((1-methyl)-cyclohexylmethoxy)benzyl]-2,4-thiazolidenedione 37°C, pH 7.5 Homo sapiens
1.1.1.141 0.005
-
 5-[4-(cyclohexylbutoxy)benzylidene]-2,4-thiazolidenedione 37°C, pH 7.5 Homo sapiens
1.1.1.141 0.017
-
 4-methoxybenzylidene-2,4-thiazolidinedione 37°C, pH 7.5 Homo sapiens
1.1.1.141 0.62
-
 4-methoxybenzyl-2,4-thiazolidinedione 37°C, pH 7.5 Homo sapiens