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Literature summary extracted from

  • Colleluori, D.M.; Morris, S.M., Jr.; Ash, D.E.
    Expression, purification, and characterization of human type II arginase (2001), Arch. Biochem. Biophys., 389, 135-143.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.3.1 medicine enzyme is a target for inhibitors used in therapeutic treatment of smooth muscle disorders, such as erectile dysfunction Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.3.1 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.1 Borate noncompetitive Homo sapiens
3.5.3.1 additional information ornithine is a poor inhibitor of isozyme type II, isozyme selectivity in binding and substrate, products, and inhibitors Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.3.1 4.8
-
 L-arginine about pH 7.0 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.3.1 mitochondrion
-
 Homo sapiens 5739
-
3.5.3.1 additional information extrahepatic Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.1 L-arginine + H2O Homo sapiens enzyme is involved in net production of ornithine, a precursor of polyamines, glutamate, and proline, enzyme is also involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase L-ornithine + urea
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.1 Homo sapiens
-
 isozyme type II
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.3.1 recombinant enzyme to homogeneity Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
3.5.3.1 L-arginine + H2O = L-ornithine + urea also hydrolyses alpha-N-substituted L-arginines and canavanine Homo sapiens
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.1 L-arginine + H2O
-
 Homo sapiens L-ornithine + urea
-
 ?
3.5.3.1 L-arginine + H2O enzyme is involved in net production of ornithine, a precursor of polyamines, glutamate, and proline, enzyme is also involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase Homo sapiens L-ornithine + urea
-
 ?
3.5.3.1 additional information isozyme selectivity in binding and substrate, products, and inhibitors Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.5.3.1 trimer primarily, higher order oligomers are also observed Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.5.3.1 type II arginase
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.5.3.1 0.3
-
 Borate
-
 Homo sapiens