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Literature summary extracted from

  • Loida, P.J.; Thompson, R.L.; Walker, D.M.; CaJacob, C.A.
    Novel inhibitors of glutamyl-tRNA(Glu) reductase identified through cell-based screening of the heme/chlorophyll biosynthetic pathway (1999), Arch. Biochem. Biophys., 372, 230-237.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.70 2,4-diphenyl-6-styryl-1-p-tolyl-pyridinium boron tetrafluoride IC50: 0.01 mM Arabidopsis thaliana
1.2.1.70 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol IC50: 0.055 mM Arabidopsis thaliana
1.2.1.70 5,6-dichloro-1,3-benzodioxol-2-one IC50: 0.055 mM Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.70 L-glutamyl-tRNAGlu + NADPH + H+ Arabidopsis thaliana the enzyme catalyzes the initial step of tetrapyrrole biosynthesis in plants and prokaryotes L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.70 Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.70 L-glutamyl-tRNAGlu + NADPH + H+
-
 Arabidopsis thaliana L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
 ?
1.2.1.70 L-glutamyl-tRNAGlu + NADPH + H+ the enzyme catalyzes the initial step of tetrapyrrole biosynthesis in plants and prokaryotes Arabidopsis thaliana L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.70 NADPH
-
 Arabidopsis thaliana

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.2.1.70 0.01
-
 IC50: 0.01 mM Arabidopsis thaliana 2,4-diphenyl-6-styryl-1-p-tolyl-pyridinium boron tetrafluoride
1.2.1.70 0.055
-
 IC50: 0.055 mM Arabidopsis thaliana 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
1.2.1.70 0.055
-
 IC50: 0.055 mM Arabidopsis thaliana 5,6-dichloro-1,3-benzodioxol-2-one