BRENDA - Enzyme Database

Novel inhibitors of glutamyl-tRNA(Glu) reductase identified through cell-based screening of the heme/chlorophyll biosynthetic pathway

Loida, P.J.; Thompson, R.L.; Walker, D.M.; CaJacob, C.A.; Arch. Biochem. Biophys. 372, 230-237 (1999)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.70
2,4-diphenyl-6-styryl-1-p-tolyl-pyridinium boron tetrafluoride
IC50: 0.01 mM
Arabidopsis thaliana
1.2.1.70
4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
IC50: 0.055 mM
Arabidopsis thaliana
1.2.1.70
5,6-dichloro-1,3-benzodioxol-2-one
IC50: 0.055 mM
Arabidopsis thaliana
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.1.70
L-glutamyl-tRNAGlu + NADPH + H+
Arabidopsis thaliana
the enzyme catalyzes the initial step of tetrapyrrole biosynthesis in plants and prokaryotes
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.2.1.70
Arabidopsis thaliana
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.70
L-glutamyl-tRNAGlu + NADPH + H+
-
654329
Arabidopsis thaliana
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
-
-
?
1.2.1.70
L-glutamyl-tRNAGlu + NADPH + H+
the enzyme catalyzes the initial step of tetrapyrrole biosynthesis in plants and prokaryotes
654329
Arabidopsis thaliana
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.2.1.70
NADPH
-
Arabidopsis thaliana
IC50 Value
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
1.2.1.70
0.01
-
IC50: 0.01 mM
Arabidopsis thaliana
2,4-diphenyl-6-styryl-1-p-tolyl-pyridinium boron tetrafluoride
1.2.1.70
0.055
-
IC50: 0.055 mM
Arabidopsis thaliana
4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
1.2.1.70
0.055
-
IC50: 0.055 mM
Arabidopsis thaliana
5,6-dichloro-1,3-benzodioxol-2-one
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.2.1.70
NADPH
-
Arabidopsis thaliana
IC50 Value (protein specific)
EC Number
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
1.2.1.70
0.01
-
IC50: 0.01 mM
Arabidopsis thaliana
2,4-diphenyl-6-styryl-1-p-tolyl-pyridinium boron tetrafluoride
1.2.1.70
0.055
-
IC50: 0.055 mM
Arabidopsis thaliana
4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
1.2.1.70
0.055
-
IC50: 0.055 mM
Arabidopsis thaliana
5,6-dichloro-1,3-benzodioxol-2-one
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.70
2,4-diphenyl-6-styryl-1-p-tolyl-pyridinium boron tetrafluoride
IC50: 0.01 mM
Arabidopsis thaliana
1.2.1.70
4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
IC50: 0.055 mM
Arabidopsis thaliana
1.2.1.70
5,6-dichloro-1,3-benzodioxol-2-one
IC50: 0.055 mM
Arabidopsis thaliana
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.1.70
L-glutamyl-tRNAGlu + NADPH + H+
Arabidopsis thaliana
the enzyme catalyzes the initial step of tetrapyrrole biosynthesis in plants and prokaryotes
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.70
L-glutamyl-tRNAGlu + NADPH + H+
-
654329
Arabidopsis thaliana
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
-
-
?
1.2.1.70
L-glutamyl-tRNAGlu + NADPH + H+
the enzyme catalyzes the initial step of tetrapyrrole biosynthesis in plants and prokaryotes
654329
Arabidopsis thaliana
L-glutamate 1-semialdehyde + NADP+ + tRNAGlu
-
-
-
?