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Literature summary extracted from

  • Holmes, M.C.; Yau, J.L.W.; Kotelevtsev, Y.; Mullins, J.J.; Seckl, J.R.
    11beta-Hydroxysteroid dehydrogenases in the brain: two enzymes two roles (2003), Ann. N. Y. Acad. Sci., 1007, 357-366.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 corticosterone + NAD+ Mus musculus
-
 11-dehydrocorticosterone + NADH + H+
-
 ir
1.1.1.B40 corticosterone + NAD+ Rattus norvegicus
-
 11-dehydrocorticosterone + NADH + H+
-
 ir
1.1.1.146 corticosterone + NADP+ Mus musculus acts as a reductase in vivo 11-dehydrocorticosterone + NADPH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Mus musculus
-
-
-
1.1.1.B40 Rattus norvegicus
-
-
-
1.1.1.146 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 brain 11beta-HSD2 in the adult brain is thought to protect mineralocorticoid receptors from inactivation by corticosterone Mus musculus
-
1.1.1.B40 brain 11beta-HSD2 in the adult brain is thought to protect mineralocorticoid receptors from inactivation by corticosterone Rattus norvegicus
-
1.1.1.B40 cerebellum
-
 Mus musculus
-
1.1.1.B40 cerebellum
-
 Rattus norvegicus
-
1.1.1.B40 hippocampus
-
 Mus musculus
-
1.1.1.B40 hippocampus
-
 Rattus norvegicus
-
1.1.1.B40 neocortex
-
 Mus musculus
-
1.1.1.B40 neocortex
-
 Rattus norvegicus
-
1.1.1.146 brain
-
 Mus musculus
-
1.1.1.146 cerebellum
-
 Mus musculus
-
1.1.1.146 hippocampus
-
 Mus musculus
-
1.1.1.146 neocortex
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 corticosterone + NAD+
-
 Mus musculus 11-dehydrocorticosterone + NADH + H+
-
 ir
1.1.1.B40 corticosterone + NAD+
-
 Rattus norvegicus 11-dehydrocorticosterone + NADH + H+
-
 ir
1.1.1.146 corticosterone + NADP+ acts as a reductase in vivo Mus musculus 11-dehydrocorticosterone + NADPH
-
 r
1.1.1.146 corticosterone + NADP+ acts as a reductase in vivo, bidirectional in vitro Mus musculus 11-dehydrocorticosterone + NADPH
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD2
-
 Mus musculus
1.1.1.B40 11beta-HSD2
-
 Rattus norvegicus
1.1.1.146 11beta-HSD1
-
 Mus musculus