Literature summary extracted from

Gomez-Sanchez, E.P.; Ganjam, V.; Chen, Y.J.; Liu, Y.; Zhou, M.Y.; Toroslu, C.; Romero, D.G.; Hughson, M.D.; de Rodriguez, A.; Gomez-Sanchez, C.E.
Regulation of 11beta-hydroxysteroid dehydrogenase enzymes in the rat kidney by estradiol (2003), Am. J. Physiol., 285, E272-279.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.1.1.B40	corticosterone + NAD+	Rattus norvegicus	-	11-dehydrocorticosterone + NADH + H+	-	ir
1.1.1.146	11-dehydrocorticosterone + NADPH	Rattus norvegicus	primarly a reductase in vivo	corticosterone + NADP+	-	r

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.1.1.B40	Rattus norvegicus	-	-	-
1.1.1.146	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.1.1.B40	kidney	11betaHSD2 mRNA and protein expression increases significantly after treatment with estradiol; renal 11beta-HSD1 mRNA and protein expression decrease to very low levels after estradiol treatment	Rattus norvegicus	-
1.1.1.146	kidney	11betaHSD2 mRNA and protein expression increases significantly after treatment with estradiol, renal 11beta-HSD1 mRNA and protein expression decrease to very low levels after estradiol treatment	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.1.1.B40	corticosterone + NAD+	-	Rattus norvegicus	11-dehydrocorticosterone + NADH + H+	-	ir
1.1.1.146	11-dehydrocorticosterone + NADPH	primarly a reductase in vivo	Rattus norvegicus	corticosterone + NADP+	-	r

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Release 2023.1 (January 2023)