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Literature summary extracted from

  • Mey, J.; Babiuk, R.P.; Clugston, R.; Zhang, W.; Greer, J.J.
    Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents (2003), Am. J. Pathol., 162, 673-679.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.36 4-biphenyl carboxylic acid 90% inhibition at 0.1 mM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo Rattus norvegicus
1.2.1.36 N,N'-octamethylenebis (dichloroacetamide) complete inhibition at very low concentration below 1 pM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo Rattus norvegicus
1.2.1.36 nitrofen 90% inhibition at 0.1 mM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo Rattus norvegicus
1.2.1.36 SB-210661 80% inhibition at 1 mM in cell culture in vivo, leads to posterolateral defects in the diaphragm in vivo Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.36 all-trans-retinal + NAD+ + H2O Rattus norvegicus key enzyme in retinoic acid biosynthesis, essential in developing diaphragm, enzyme inhibition or disfunction causes the serious developmental anomaly congenital diaphragmatic hernia, i.e. CDH all-trans-retinoic acid + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.36 Rattus norvegicus
-
 18-days-pregnant Sprague-Dawley rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.36 partially by isoelectric focusing Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.36 diaphragm
-
 Rattus norvegicus
-
1.2.1.36 oligodendrocyte cell culture Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.36 all-trans-retinal + NAD+ + H2O
-
 Rattus norvegicus all-trans-retinoic acid + NADH
-
 ?
1.2.1.36 all-trans-retinal + NAD+ + H2O key enzyme in retinoic acid biosynthesis, essential in developing diaphragm, enzyme inhibition or disfunction causes the serious developmental anomaly congenital diaphragmatic hernia, i.e. CDH Rattus norvegicus all-trans-retinoic acid + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.36 RALDH2
-
 Rattus norvegicus
1.2.1.36 retinal dehydrogenase-2
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.36 37
-
 assay at Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.36 NAD+
-
 Rattus norvegicus