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Literature summary extracted from

  • Tai, H.H.; Ensor, C.M.; Zhou, H.; Yan, F.
    Structure and function of human NAD+-linked 15-hydroxyprostaglandin dehydrogenase (2002), Adv. Exp. Med. Biol., 507, 245-250.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.141
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.141 C152A similar activity as wild-type Homo sapiens
1.1.1.141 C152F no activity Homo sapiens
1.1.1.141 C182A no activity Homo sapiens
1.1.1.141 C182F no activity Homo sapiens
1.1.1.141 C42A similar activity as wild-type Homo sapiens
1.1.1.141 C45F similar activity as wild-type Homo sapiens
1.1.1.141 C63A similar activity as wild-type Homo sapiens
1.1.1.141 C63F 10% of wild-type activity Homo sapiens
1.1.1.141 D64E no activity Homo sapiens
1.1.1.141 D64K low activity Homo sapiens
1.1.1.141 D64N similar activity as wild type Homo sapiens
1.1.1.141 D86E similar activity as wild type Homo sapiens
1.1.1.141 D86N similar activity as wild type Homo sapiens
1.1.1.141 L155L no activity Homo sapiens
1.1.1.141 L155Q no activity Homo sapiens
1.1.1.141 additional information C-terminal truncation decreases activity Homo sapiens
1.1.1.141 S138A no activity Homo sapiens
1.1.1.141 T188A no activity Homo sapiens
1.1.1.141 T188S substantial activity, lower than wild-type Homo sapiens
1.1.1.141 T188Y no activity Homo sapiens
1.1.1.141 Y151A no activity Homo sapiens
1.1.1.141 Y151F no activity Homo sapiens
1.1.1.141 Y151S no activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.141 0.0039
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate
-
 Homo sapiens
1.1.1.141 0.046
-
 NAD+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+ Homo sapiens
-
 (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.141 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.141 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
-
 Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.141 15-PGDH
-
 Homo sapiens