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Literature summary extracted from
- Insulin-degrading enzyme: embarking on amyloid destruction (2001), Trends Biochem. Sci., 26, 421-425.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.24.56 | medicine | stimulation of enzyme activity can provide a useful therapeutic approach in treatment of diseases caused by amyloidosis, like Alzheimer's disease, type2 non-insulin-dependent diabetes and the spongiform encephalopathies such as Creutzfeldt-Jakob disease | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.56 | cDNA cloned and expressed | Drosophila melanogaster |
| 3.4.24.56 | expressed in bacteria | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.24.56 | 0.00002 | - |
Insulin | - |
Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.56 | cytosol | - |
Drosophila melanogaster | 5829 | - |
| 3.4.24.56 | cytosol | - |
Homo sapiens | 5829 | - |
| 3.4.24.56 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 3.4.24.56 | peroxisome | - |
Drosophila melanogaster | 5777 | - |
| 3.4.24.56 | peroxisome | - |
Homo sapiens | 5777 | - |
| 3.4.24.56 | peroxisome | - |
Rattus norvegicus | 5777 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.56 | Zn2+ | contains zinc, essential for its proteolytic activity | Homo sapiens |  |
| 3.4.24.56 | Zn2+ | zinc metallomeptidase | Drosophila melanogaster | |
| 3.4.24.56 | Zn2+ | zinc metallomeptidase | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.56 | 110000 | - |
3 * 110000, SDS-PAGE | Homo sapiens |
| 3.4.24.56 | 300000 | - |
gel filtration | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.56 | Drosophila melanogaster | - |
fruit fly | - |
| 3.4.24.56 | Homo sapiens | - |
human | - |
| 3.4.24.56 | Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.56 | - |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.56 | amylin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.56 | atrial natriuretic peptide + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.56 | beta-amyloid protein + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.56 | beta-amyloid protein + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.24.56 | beta-endorphin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.56 | calcitonin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.56 | Glucagon + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.56 | haemoglobin + H2O | damaged haemoglobin oxidatively degraded | Homo sapiens | ? | - |
? | |
| 3.4.24.56 | insulin + H2O | - |
Drosophila melanogaster | ? | - |
? | |
| 3.4.24.56 | insulin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.56 | insulin + H2O | - |
Rattus norvegicus | ? | - |
? | |
| 3.4.24.56 | Lysozyme + H2O | degradation of oxidatively damaged lysozyme | Homo sapiens | ? | - |
? | |
| 3.4.24.56 | additional information | does not act on glucagon-like peptide 1, nerve growth factor, somatostatin, bradykinin, vasopressin, platelet-derived growth factor, and vasoactive intestinal peptide, proinsulin, epidermal growth factor and IGF-I bind to the enzyme but are not efficiently degraded | Homo sapiens | ? | - |
? | |
| 3.4.24.56 | transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.24.56 | trimer | 3 * 110000, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.56 | ADE | - |
Drosophila melanogaster |
| 3.4.24.56 | ADE | - |
Homo sapiens |
| 3.4.24.56 | ADE | - |
Rattus norvegicus |
| 3.4.24.56 | amyloid degrading enzyme | - |
Drosophila melanogaster |
| 3.4.24.56 | amyloid degrading enzyme | - |
Homo sapiens |
| 3.4.24.56 | amyloid degrading enzyme | - |
Rattus norvegicus |
| 3.4.24.56 | gamma-endorphin-generating enzyme | - |
Homo sapiens |
| 3.4.24.56 | IDE | - |
Drosophila melanogaster |
| 3.4.24.56 | IDE | - |
Homo sapiens |
| 3.4.24.56 | IDE | - |
Rattus norvegicus |
| 3.4.24.56 | insulin degrading enzyme | - |
Drosophila melanogaster |
| 3.4.24.56 | Insulin protease | - |
Rattus norvegicus |
| 3.4.24.56 | Insulin-degrading enzyme | - |
Homo sapiens |
| 3.4.24.56 | Insulin-degrading enzyme | - |
Rattus norvegicus |
| 3.4.24.56 | Insulinase | - |
Homo sapiens |
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