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Literature summary extracted from

  • Walsh, A.C.; Feulner, J.A.; Reilly, A.
    Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit: association with glutathione levels and drug resistance in the National Cancer Institute tumor cell line panel (2001), Toxicol. Sci., 61, 218-223.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.2 DNA sequence determination and analysis, heterodimer of a catalytic subunit and a regulatory subunit, encoded by 2 genes: GLCLC for the catalytic subunit, and GLCLR for the regulatory subunit, GLCLC polymorphism and existence of 5 alleles as defined by the trinucleotide repeat, which exhibits a range of 4 to 10 uninterrupted repeat, genotyping for the repeat of 60 tumor cancer cell lines, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.2 additional information the genotype of GLCLC is associated with drug sensitivity or resistance, respectively, sensitivity of different genotypes to diverse drugs, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.2 ATP + L-Glu + L-Cys Homo sapiens first and rate limiting step in glutathione biosynthesis ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?
6.3.2.2 additional information Homo sapiens the genotype of GLCLC is associated with drug sensitivity or resistance, respectively ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.2.2 additional information genotyping of 60 tumor cell lines from diverse source tissues for the GLCLC trinuleotide repeat Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.2 ATP + L-Glu + L-Cys
-
 Homo sapiens ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?
6.3.2.2 ATP + L-Glu + L-Cys first and rate limiting step in glutathione biosynthesis Homo sapiens ADP + phosphate + gamma-L-Glu-L-Cys
-
 ?
6.3.2.2 additional information the genotype of GLCLC is associated with drug sensitivity or resistance, respectively Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
6.3.2.2 dimer heterodimer of a catalytic subunit and a regulatory subunit, encoded by 2 genes Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
6.3.2.2 GCL
-
 Homo sapiens
6.3.2.2 GLCLC
-
 Homo sapiens
6.3.2.2 GLCLR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.3.2.2 ATP
-
 Homo sapiens