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Literature summary extracted from

  • Ashani, Y.; Segev, O.; Balan, A.
    The effect of fluoride on the scavenging of organophosphates by human butyrylcholinesterase in buffer solutions and human plasma (2004), Toxicol. Appl. Pharmacol., 194, 90-99.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.8 diisopropyl phosphorofluoridate rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon Homo sapiens
3.1.1.8 fluoride reversible inhibitor, forms a complex with the enzyme Homo sapiens
3.1.1.8 O,O-diethyl-4-nitrophenylphosphate syn: paraoxon, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon Homo sapiens
3.1.1.8 O,O-diethyl-S-(2-N,N,N-trimethylammonioethyl) phosphorothiolate iodide syn: echothiophate, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon Homo sapiens
3.1.1.8 O-isopropyl methylphosphonofluoridate syn: sarin, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon Homo sapiens
3.1.1.8 O-pinacolyl methylphosphonofluoridate syn: soman, rank order of decreasing inhibition: soman, sarin, diisopropyl phosphorofluoridate, echothiohate, paraoxon Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 butyrylthiocholine iodide + H2O
-
Homo sapiens thiocholine iodide + butyrate
-
?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.1.8 55
-
25% remaining activity after 25 min, heat inactivation is retarded in the presence of 2 mM fluoride Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.8 additional information
-
additional information
-
Homo sapiens