Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bonnefoy, A.; Legrand, C.
    Proteolysis of subendothelial adhesive glycoproteins (fibronectin, thrombospondin, and von Willebrand factor) by plasmin, leukocyte cathepsin G, and elastase (2000), Thromb. Res., 98, 323-332.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.20 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.20 fibronectin + H2O Homo sapiens proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation peptide fragments
-
 ?
3.4.21.20 thrombospondin + H2O Homo sapiens proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation peptide fragments
-
 ?
3.4.21.20 von Willebrand factor + H2O Homo sapiens proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation peptide fragments
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.20 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.20 commercial preparation from leukocytes Homo sapiens
-
3.4.21.20 leukocyte
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.20 148
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.20 fibronectin + H2O 220 kDa substrate in extracellular matrix of human umbilical vein endothelial cells and platelets Homo sapiens peptide fragments 162 kDa, 122 kDa, and 92 kDa ?
3.4.21.20 fibronectin + H2O proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation Homo sapiens peptide fragments
-
 ?
3.4.21.20 thrombospondin + H2O preferred substrate, 180 kDa substrate in extracellular matrix of human umbilical vein endothelial cells and platelets Homo sapiens peptide fragments 155 kDa and 25 kDa ?
3.4.21.20 thrombospondin + H2O proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation Homo sapiens peptide fragments
-
 ?
3.4.21.20 von Willebrand factor + H2O 280 kDa substrate in extracellular matrix of human umbilical vein endothelial cells and platelets Homo sapiens peptide fragments 260-177 kDa and 177-136 kDa ?
3.4.21.20 von Willebrand factor + H2O proteolysis causes no change in endothelial cell morphology, involved in release of extracellular matrix components during inflammation Homo sapiens peptide fragments
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.21.20 37
-
 assay at Homo sapiens