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Literature summary extracted from

  • de Bosch, N.B.; Mosesson, M.W.; Ruiz-Saez, A.; Echenagucia, M.; Rodriguez-Lemoin, A.
    Inhibition of thrombin generation in plasma by fibrin formation (antithrombin I) (2002), Thromb. Haemost., 88, 253-258.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.5 additional information defibrination of plasma results in an increased rate of thrombin generation Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.5 additional information defective mutant enzymes of 2 humans with congenital afibrinogenemia, termed MC and KU, show impaired binding of thrombin to the thrombin binding sites of fibrin and fibrin gamma' peptides, respectively Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.5 fibrinogen 1 down-regulation of thrombin production Homo sapiens
3.4.21.5 fibrinogen 2 more potent inhibition compared to fibrinogen 1, down-regulation of thromin production Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.5 extracellular plasma Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.5 fibrinogen 1 + H2O Homo sapiens
-
 fibrin 1 + fibrinopeptide A + fibrinopeptide B
-
 ?
3.4.21.5 fibrinogen 2 + H2O Homo sapiens
-
 fibrin 2 + fibrinopeptide A + fibrinopeptide B
-
 ?
3.4.21.5 additional information Homo sapiens enzyme deficienxy leads to umbilical cord bleeding at birth, development of hematoma, diminished vitamin K-dependent clotting factor, thrombocytopenia, and at least to lethal retroperitoneal bleeding ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.5 Homo sapiens
-
 enzyme from platelet-poor plasma of 2 humans with congenital afibrinogenemia, termed MC and KU
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.5 plasma platelet-poor Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.5 fibrinogen + H2O
-
 Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?
3.4.21.5 fibrinogen 1 + H2O
-
 Homo sapiens fibrin 1 + fibrinopeptide A + fibrinopeptide B
-
 ?
3.4.21.5 fibrinogen 2 + H2O
-
 Homo sapiens fibrin 2 + fibrinopeptide A + fibrinopeptide B
-
 ?
3.4.21.5 additional information enzyme deficienxy leads to umbilical cord bleeding at birth, development of hematoma, diminished vitamin K-dependent clotting factor, thrombocytopenia, and at least to lethal retroperitoneal bleeding Homo sapiens ?
-
 ?