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Literature summary extracted from

  • Pejler, G.; Lunderius, C.; Tomasini-Johansson, B.
    Macrophages synthesize factor X and secrete factor X/Xa-containing prothrombinase activity into the surrounding medium (2000), Thromb. Haemost., 84, 429-435.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.6 actinomycin no remaining enzyme activityafter 20 h Mus musculus
3.4.21.6 cycloheximide 61% inhibition at 0.01 mg/ml after 3 h, complete inhibition after 20 h Mus musculus
3.4.21.6 EDTA complete inhibition at 10 mM Mus musculus
3.4.21.6 Triton X-100 complete inactivation at 0.05% Mus musculus
3.4.21.6 vitamin K induction of enzyme activity Mus musculus
3.4.21.6 warfarin 62% inhibition at 0.02 mg/ml after 3 h, and 90% after 20 h Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.6 extracellular secretion to the medium Mus musculus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.6 45000
-
 x * 45000, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.6 prothrombin + H2O Mus musculus
-
 thrombin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Mus musculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.6 selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Mus musculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.6 macrophage peritoneal Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.6 prothrombin + H2O
-
 Mus musculus thrombin + ?
-
 ?
3.4.21.6 S2222 + H2O chromogenic synthetic peptide substrate Mus musculus ?
-
 ?
3.4.21.6 S2238 + H2O chromogenic synthetic peptide substrate Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.6 ? x * 45000, SDS-PAGE Mus musculus
3.4.21.6 More factor Xa is part of the prothrombinase complex Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 More the enzyme belongs to the peptidase family S1, i.e. trypsin family Mus musculus
3.4.21.6 prothrombinase
-
 Mus musculus