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Literature summary extracted from
- Dermatan sulfate and LMW heparin enhance the anticoagulant action of activated protein C (1999), Thromb. Haemost., 82, 1462-1468.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.69 | certoparin | clinical LMWH enhances activity | Homo sapiens | |
| 3.4.21.69 | dalteparin | clinical LMWH enhances activity | Homo sapiens | |
| 3.4.21.69 | dermatan sulfate | shows potent APC enhancing effect | Homo sapiens |  |
| 3.4.21.69 | enoxaparin | clinical LMWH enhances activity | Homo sapiens | |
| 3.4.21.69 | glycosaminoglycan | enhances activity with factor V but not with factor Va as substrate | Homo sapiens | |
| 3.4.21.69 | LMW heparin | enhances the anticoagulant action of activated protein C | Homo sapiens | |
| 3.4.21.69 | nadroparin | clinical LMWH enhances activity | Homo sapiens | |
| 3.4.21.69 | tinzaparin | clinical LMWH enhances activity | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.69 | factor V + H2O | Homo sapiens | proteolytic inactivation | ? | - |
? | |
| 3.4.21.69 | factor VIII + H2O | Homo sapiens | proteolytic inactivation | ? | - |
? | |
| 3.4.21.69 | Factor VIIIa + H2O | Homo sapiens | #> | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.69 | Homo sapiens | - |
human | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.69 | - |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.69 | factor V + H2O | proteolytic inactivation | Homo sapiens | ? | - |
? | |
| 3.4.21.69 | factor VIII + H2O | proteolytic inactivation | Homo sapiens | ? | - |
? | |
| 3.4.21.69 | Factor VIIIa + H2O | proteolytic inactivation | Homo sapiens | ? | - |
? | |
| 3.4.21.69 | Factor VIIIa + H2O | #> | Homo sapiens | ? | - |
? | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.69 | chondroitin sulfate | anticoagulant cofactor for APC | Homo sapiens | |
| 3.4.21.69 | dermatan sulfate | anticoagulant cofactor for APC, important physiological cofactor | Homo sapiens | |
| 3.4.21.69 | heparan sulfate | anticoagulant cofactor for APC | Homo sapiens | |
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