BRENDA - Enzyme Database

The crystal structure and active site location of isocitrate lyase from the fungus Aspergillus nidulans

Britton, K.; Langridge, S.; Baker, P.J.; Weeradechapon, K.; Sedelnikova, S.E.; De Lucas, J.R.; Rice, D.W.; Turner, G.; Structure 8, 349-362 (2000)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
4.1.3.1
medicine
enzyme provides a potential target for drug design aimed at the control of parasitic infections
Aspergillus nidulans
Crystallization (Commentary)
EC Number
Crystallization
Organism
4.1.3.1
complexed with glyoxylate and a divalent cation
Aspergillus nidulans
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
4.1.3.1
Mg2+
dependent
Aspergillus nidulans
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.1.3.1
isocitrate
Aspergillus nidulans
-
succinate + glyoxylate
-
Aspergillus nidulans
r
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.1.3.1
Aspergillus nidulans
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.3.1
isocitrate
-
653939
Aspergillus nidulans
succinate + glyoxylate
-
653939
Aspergillus nidulans
r
Subunits
EC Number
Subunits
Commentary
Organism
4.1.3.1
tetramer
crystallization experiments
Aspergillus nidulans
Application (protein specific)
EC Number
Application
Commentary
Organism
4.1.3.1
medicine
enzyme provides a potential target for drug design aimed at the control of parasitic infections
Aspergillus nidulans
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
4.1.3.1
complexed with glyoxylate and a divalent cation
Aspergillus nidulans
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
4.1.3.1
Mg2+
dependent
Aspergillus nidulans
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.1.3.1
isocitrate
Aspergillus nidulans
-
succinate + glyoxylate
-
Aspergillus nidulans
r
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.1.3.1
isocitrate
-
653939
Aspergillus nidulans
succinate + glyoxylate
-
653939
Aspergillus nidulans
r
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
4.1.3.1
tetramer
crystallization experiments
Aspergillus nidulans