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Literature summary extracted from

  • Levdikov, V.M.; Barynin, V.V.; Grebenko, A.I.; Melik-Adamyan, W.R.; Lamzin, V.S.; Wilson, K.S.
    The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis (1998), Structure, 6, 363-376.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.3.2.6 hanging drop vapor diffusion, drops contain protein at a concentration of 8-15 mg/ml in 50 mM Tris-HCl, pH 7.0, 40 mM aspartic acid and 1.0-1.25 M ammonium sulfate, crystals diffract to 1.9 A resolution Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate Saccharomyces cerevisiae
-
 ADP + phosphate + (S)-2-[5-amino1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.6 Saccharomyces cerevisiae P27616
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.2.6 ammonium sulfate, DEAE-Sephadex, Butyl-Toyopearl Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.6 ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate
-
 Saccharomyces cerevisiae ADP + phosphate + (S)-2-[5-amino1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.6 SAICAR synthase
-
 Saccharomyces cerevisiae