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Literature summary extracted from

  • Starai, V.J.; Celic, I.; Cole, R.N.; Boeke, J.D.; Escalante-Semerena, J.C.
    Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine (2002), Science, 298, 2390-2392.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
6.2.1.1 CobB Sir2 protein activation of the acetylated enzyme requires the nicotinamide adenine dinucleotide-dependent protein deacetylase activity of the CobB Sir2 protein Salmonella enterica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.B43 NAD+ + [acetyl-coenzyme A synthetase]-N6-acetyl-L-lysine609 Salmonella enterica deacetylation by CobB activates the acetyl-coenzyme A synthetase nicotinamide + [acetyl-coenzyme A synthetase]-L-lysine609 + 2'-O-acetyl-ADP-ribose
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B43 Salmonella enterica
-
-
-
6.2.1.1 Salmonella enterica
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.2.1.1 acetylation posttranslational regulation by acetylation of Lys609. Acetylation blocks synthesis of the adenylate intermediate but does not affect the thioester-forming activity of the enzyme Salmonella enterica

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B43 NAD+ + [acetyl-coenzyme A synthetase]-N6-acetyl-L-lysine609
-
 Salmonella enterica nicotinamide + [acetyl-coenzyme A synthetase]-L-lysine609 + 2'-O-acetyl-ADP-ribose
-
 ?
2.3.1.B43 NAD+ + [acetyl-coenzyme A synthetase]-N6-acetyl-L-lysine609 deacetylation by CobB activates the acetyl-coenzyme A synthetase Salmonella enterica nicotinamide + [acetyl-coenzyme A synthetase]-L-lysine609 + 2'-O-acetyl-ADP-ribose
-
 ?
6.2.1.1 ATP + acetate + CoA
-
 Salmonella enterica AMP + diphosphate + acetyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B43 CobB Sir2 protein
-
 Salmonella enterica
6.2.1.1 ACS
-
 Salmonella enterica

General Information

EC Number General Information Comment Organism
2.3.1.B43 malfunction acetyl-coenzyme A synthetase overproduced by the cobB deletion mutant strain contains acetyllysine at residue Lys609 Salmonella enterica
2.3.1.B43 physiological function deacetylation by CobB activates the acetyl-coenzyme A synthetase Salmonella enterica