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Literature summary extracted from

  • Schnaufer, A.; Panigrahi, A.K.; Panicucci, B.; Igo, R.P., Jr.; Wirtz, E.; Salavati, R.; Stuart, K.
    An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei (2001), Science, 291, 2159-2162.
    View publication on PubMed

Application

EC Number Application Comment Organism
6.5.1.3 medicine regulated repression of the enzyme blocks editing, this repression is lethal in bloodforms of the parasite, indicating that editing is essential in the mammalian stage of the life cycle, the editing complex, which is present in all kinetoplastid parasites, may thus be a chemotherapeutic target Trypanosoma brucei

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.5.1.3
-
 Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.5.1.3 mitochondrion
-
 Trypanosoma brucei 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.3 ATP + (ribonucleotide)n + (ribonucleotide)m Trypanosoma brucei RNA editing, essential for proliferation of Trypanosoma brucei AMP + diphosphate + (ribonucleotide)n+m
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.3 Trypanosoma brucei
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.5.1.3 editing complex Trypanosoma brucei

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.3 ATP + (ribonucleotide)n + (ribonucleotide)m
-
 Trypanosoma brucei AMP + diphosphate + (ribonucleotide)n+m
-
 ?
6.5.1.3 ATP + (ribonucleotide)n + (ribonucleotide)m RNA editing, essential for proliferation of Trypanosoma brucei Trypanosoma brucei AMP + diphosphate + (ribonucleotide)n+m
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.3 TbMP52 macromolecular complex with RNA ligase activity Trypanosoma brucei