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Literature summary extracted from

  • Silvian, L.F.; Wang, J.; Steitz, T.A.
    Insights into editing from an Ile-tRNA synthetase structure with tRNAIle and mupirocin (1999), Science, 285, 1074-1077.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
6.1.1.5 purified recombinant enzyme cocrystallized with Escherichia coli tRNAIle and inhibitor muciproin, formation of the socalled editing complex, X-ray diffraction structure determination at 2.2 A resolution, and structure analysis Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.5 muciproin
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.5 ATP + L-isoleucine + tRNAIle Staphylococcus aureus
-
 AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.5 Staphylococcus aureus P41972
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.5 ATP + L-isoleucine + tRNAIle = AMP + diphosphate + L-isoleucyl-tRNAIle active site structure and mechanism Staphylococcus aureus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.5 ATP + L-isoleucine + tRNAIle
-
 Staphylococcus aureus AMP + diphosphate + L-isoleucyl-tRNAIle
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.5 IleRS
-
 Staphylococcus aureus
6.1.1.5 IRS
-
 Staphylococcus aureus
6.1.1.5 Isoleucine translase
-
 Staphylococcus aureus
6.1.1.5 Isoleucine--tRNA ligase
-
 Staphylococcus aureus
6.1.1.5 Isoleucine-transfer RNA ligase
-
 Staphylococcus aureus
6.1.1.5 Isoleucine-tRNA synthetase
-
 Staphylococcus aureus
6.1.1.5 Isoleucyl-transfer ribonucleate synthetase
-
 Staphylococcus aureus
6.1.1.5 Isoleucyl-transfer RNA synthetase
-
 Staphylococcus aureus
6.1.1.5 Isoleucyl-tRNA synthetase
-
 Staphylococcus aureus
6.1.1.5 Mupirocin resistance protein
-
 Staphylococcus aureus
6.1.1.5 Synthetase, isoleucyl-transfer ribonucleate
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.5 ATP
-
 Staphylococcus aureus