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Literature summary extracted from

  • Kua, J.; Zhang, Y.; Eslami, A.C.; Butler, J.R.; McCammon, J.A.
    Studying the roles of W86, E202, and Y337 in binding of acetylcholine to acetylcholinesterase using a combined molecular dynamics and multiple docking approach (2003), Protein Sci., 12, 2675-2684.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.7
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.1.1.7 E202A results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
3.1.1.7 E202D results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
3.1.1.7 E202Q results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
3.1.1.7 W68A results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
3.1.1.7 W68F results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
3.1.1.7 Y337A results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens
3.1.1.7 Y337F results in significant reduction in binding of extended acetylcholine in the catalytically productive orientation Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.1.7 0.043
-
 acetylthiocholine E202Q mutant Homo sapiens
3.1.1.7 0.046
-
 acetylthiocholine wild-type enzyme Homo sapiens
3.1.1.7 0.053
-
 acetylthiocholine Y337F mutant Homo sapiens
3.1.1.7 0.11
-
 acetylthiocholine Y337A mutant Homo sapiens
3.1.1.7 0.276
-
 acetylthiocholine W68F mutant Homo sapiens
3.1.1.7 0.66
-
 acetylthiocholine E202D mutant Homo sapiens
3.1.1.7 30.64
-
 acetylthiocholine W68A mutant Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.7 acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?