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Literature summary extracted from

  • Gholizadeh, Y.; Prevost, M.; Van Bambeke, F.; Casadewall, B.; Tulkens, P.M.; Courvalin, P.
    Sequencing of the ddl gene and modeling of the mutated D-alanine:D-alanine ligase in glycopeptide-dependent strains of Enterococcus faecium (2001), Protein Sci., 10, 836-844.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.2.4
-
 Enterococcus faecium

Protein Variants

EC Number Protein Variants Comment Organism
6.3.2.4 additional information 9 clinical isolates that show high resistance to vancomycin have mutations in the Ddl gene, lack of growth of these mutants in the absence of vancomycin is most probably due to a complete loss of Ddl activity Enterococcus faecium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.3.2.4 ATP + D-alanine Enterococcus faecium
-
 ADP + phosphate + D-alanyl-D-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.4 Enterococcus faecium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.4 ATP + D-alanine
-
 Enterococcus faecium ADP + phosphate + D-alanyl-D-alanine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.4 Ddl
-
 Enterococcus faecium