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Literature summary extracted from

  • Buck, J.; Sinclair, M.L.; Schapal, L.; Cann, M.J.; Levin, L.R.
    Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals (1999), Proc. Natl. Acad. Sci. USA, 96, 79-84.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 additional information completely insensitiv to forskolin and GTPgammaS Rattus norvegicus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.1 expression of full length and C-terminal truncated sAC in HEK293 cells Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.6.1.1 1.2
-
 ATP sAC activity in cytosolic extracts in the presence of Mn2+ Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.1 cytosol
-
 Rattus norvegicus 5829
-
4.6.1.1 soluble
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.1 Mn2+ required for activity Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.6.1.1 48000
-
 x * 48000, SDS-PAGE, proteolytically processed active form Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.1 ATP Rattus norvegicus
-
 3',5'-cyclic AMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Rattus norvegicus Q9Z286
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.1
-
 Rattus norvegicus

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.6.1.1 920 3000
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Rattus norvegicus 3',5'-cyclic AMP + diphosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
4.6.1.1 ? x * 48000, SDS-PAGE, proteolytically processed active form Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 sAC
-
 Rattus norvegicus
4.6.1.1 soluble adenylyl cyclase
-
 Rattus norvegicus