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Literature summary extracted from

  • Wolfsberg, T.G.; Bazan, J.F.; Blobel, C.P.; Myles, D.G.; Primakoff, P.; White, J.M.
    The precursor region of a protein active in sperm-egg fusion contains a metalloprotease and a disintegrin domain: structural, functional, and evolutionary implications (1993), Proc. Natl. Acad. Sci. USA, 90, 10783-10787.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B8 membrane on the cell surface Cavia porcellus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.B8 Zn2+ metalloprotease domain in the beta subunit precursor region, but not in the mature protein, the alpha-subunit conatins a metalloprotease domain, which is the active site, in the mature from with the consensus sequence HEXXHXXGXXHE Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B8 additional information Cavia porcellus the enzyme mediates the cell-cell membrane fusion of egg and sperm ?
-
 ?
3.4.24.B8 proteins + H2O Cavia porcellus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B8 Cavia porcellus Q60410
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B8 proteolytic modification processing of the subunit a and b precursors to mature proteins during sperm development Cavia porcellus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.24.B8 proteolytic degradation of proteins mechanism Cavia porcellus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B8 sperm
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B8 additional information the enzyme mediates the cell-cell membrane fusion of egg and sperm Cavia porcellus ?
-
 ?
3.4.24.B8 proteins + H2O
-
 Cavia porcellus peptides
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.B8 More domain organization, the alpha subunit contains a putative fusion peptide, beta subunit contains a soluble disintegrin ligand Cavia porcellus

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B8 M12.201 Merops-ID Cavia porcellus
3.4.24.B8 PH-30
-
 Cavia porcellus