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Literature summary extracted from

  • Miller, B.C.; Eckman, E.A.; Sambamurti, K.; Dobbs, N.; Chow, K.M.; Eckman, C.B.; Hersh, L.B.; Thiele, D.L.
    Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo (2003), Proc. Natl. Acad. Sci. USA, 100, 6221-6226.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.24.56 medicine inverse correlation between insulysin activity levels and brain Abeta peptide levels suggest that modulation of insulysin activity may alter the risk for Alzheimer's disease Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.56
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.56 Zn2+ zinc metalloprotease Rattus norvegicus
3.4.24.56 Zn2+ zinc metalloprotease Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.56 110000 115000 SDS-PAGE Mus musculus
3.4.24.56 113000
-
 Western blot Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Mus musculus Q8CGB9 mouse, Omnibank B6.129
-
3.4.24.56 Rattus norvegicus
-
 rat
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 amyloid-beta peptide + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 amyloid-beta peptide + H2O
-
 Mus musculus ?
-
 ?
3.4.24.56 beta-endorphin + H2O
-
 Rattus norvegicus gamma-endorphin + ?
-
 ?
3.4.24.56 beta-endorphin + H2O
-
 Mus musculus gamma-endorphin + ?
-
 ?
3.4.24.56 insulin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 insulin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
 Rattus norvegicus
3.4.24.56 IDE
-
 Mus musculus