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Literature summary extracted from

  • Brguljan, P.M.; Turk, V.; Nina, C.; Brzin, J.; Krizaj, I.; Popovic, T.
    Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme (2003), Peptides, 24, 1977-1984.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.16 cystatin C, full-length
-
 Homo sapiens
3.4.22.16 cystatin C, truncated form deletion of 10 N-terminal amino acids Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.16 30000
-
 x * 30000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.16 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.16 brain
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.22.16 2
-
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.16 alpha-neoendorphin + H2O preferentially aminopeptidase activity, endoeptidase activity after prolonged incubation Homo sapiens ?
-
 ?
3.4.22.16 bradykinin + H2O no aminopeptidase activity, endopeptidase activity after prolonged incubation Homo sapiens ?
-
 ?
3.4.22.16 demorphin + H2O no aminopeptidase activity, endopeptidase activity after prolonged incubation Homo sapiens ?
-
 ?
3.4.22.16 dynorphin(1-13) + H2O preferentially aminopeptidase activity, endoeptidase activity after prolonged incubation Homo sapiens ?
-
 ?
3.4.22.16 dynorphin(1-6) + H2O preferentially aminopeptidase activity, endoeptidase activity after prolonged incubation Homo sapiens ?
-
 ?
3.4.22.16 Leu-enkephalin + H2O preferentially aminopeptidase activity, endoeptidase activity after prolonged incubation Homo sapiens ?
-
 ?
3.4.22.16 Lys-bradykinin + H2O preferentially aminopeptidase activity, endoeptidase activity after prolonged incubation Homo sapiens ?
-
 ?
3.4.22.16 neurotensin + H2O no aminopeptidase activity, endopeptidase activity after prolonged incubation Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.16 ? x * 30000, SDS-PAGE Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.4.22.16 0.000000071
-
 cystatin C, full-length 25°C, pH 7.0 Homo sapiens
3.4.22.16 0.00000032
-
 cystatin C, truncated form 25°C, pH 7.0 Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
3.4.22.16 Homo sapiens and minor band at 6.1, isoelectric focusing 6.8 6.3