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Literature summary extracted from

  • Noel, A.; Boulay, A.; Kebers, F.; Kannan, R.; Hajitou, A.; Calberg-Bacq, C.M.; Basset, P.; Rio, M.C.; Foidart, J.M.
    Demonstration in vivo that stromelysin-3 functions through its proteolytic activity (2000), Oncogene, 19, 1605-1612.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.B3 overexpression of wild-type and mutant E220A in Escherichia coli, expression of wild-type and inactive enzyme in MCF7 carcinoma cells Mus musculus
3.4.24.B3 overexpression of wild-type and mutant E220A in Escherichia coli, expression of wild-type and inactive enzyme in MCF7 carcinoma cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.24.B3 E216A site-directed mutagenesis, exchange of a residue in the zinc-binding catalytic domain, inactive Homo sapiens
3.4.24.B3 E220A site-directed mutagenesis, exchange of a residue in the zinc-binding catalytic domain, inactive Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.B3 matrix metalloprotease inhibitor TIMP-2
-
 Homo sapiens
3.4.24.B3 matrix metalloprotease inhibitor TIMP-2
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B3 protein + H2O Mus musculus the enzyme promotes and modulates tumor progression peptides
-
 ?
3.4.24.B3 protein + H2O Homo sapiens the enzyme promotes and modulates tumor progression peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B3 Homo sapiens
-
-
-
3.4.24.B3 Mus musculus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.24.B3 proteolytic modification
-
 Mus musculus
3.4.24.B3 proteolytic modification
-
 Homo sapiens

Renatured (Commentary)

EC Number Renatured (Comment) Organism
3.4.24.B3 refolding of recombinant enzyme from inclusion bodies after overexpression in Escherichia coli Mus musculus
3.4.24.B3 refolding of recombinant enzyme from inclusion bodies after overexpression in Escherichia coli Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B3 alpha1-protease inhibitor + H2O
-
 Mus musculus ?
-
 ?
3.4.24.B3 alpha1-protease inhibitor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.B3 protein + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B3 protein + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B3 protein + H2O the enzyme promotes and modulates tumor progression Mus musculus peptides
-
 ?
3.4.24.B3 protein + H2O the enzyme promotes and modulates tumor progression Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B3 M10.007 Merops-ID Mus musculus
3.4.24.B3 M10.007 Merops-ID Homo sapiens
3.4.24.B3 matrix metalloproteinase-11
-
 Mus musculus
3.4.24.B3 matrix metalloproteinase-11
-
 Homo sapiens
3.4.24.B3 matrixin 11
-
 Mus musculus
3.4.24.B3 matrixin 11
-
 Homo sapiens
3.4.24.B3 MMP-11
-
 Mus musculus
3.4.24.B3 MMP-11
-
 Homo sapiens