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Literature summary extracted from

  • Ramos, W.; Liu, G.; Giroux, C.N.; Tomkinson, A.E.
    Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces cerevisiae open reading frame YOR005c, a homolog of mammalian DNA ligase IV (1998), Nucleic Acids Res., 26, 5676-5683.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.5.1.1 in vitro transcription and translation Saccharomyces cerevisiae

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.5.1.1 90000
-
 x * 90000, SDS-PAGE Saccharomyces cerevisiae
6.5.1.1 104000
-
 x * 104000, deduced from nucleotide sequence Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Saccharomyces cerevisiae probably involved in non-homologous end joining repair mechanism AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Saccharomyces cerevisiae Q08387 inactivation of DNL4 gene causes temperature-sensitive growth
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.5.1.1 hydroxyapatite column, partially purified Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Saccharomyces cerevisiae AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m probably involved in non-homologous end joining repair mechanism Saccharomyces cerevisiae AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Subunits

EC Number Subunits Comment Organism
6.5.1.1 ? x * 90000, SDS-PAGE Saccharomyces cerevisiae
6.5.1.1 ? x * 104000, deduced from nucleotide sequence Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 Dnl4
-
 Saccharomyces cerevisiae