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Literature summary extracted from
- Cloning and expression of human placental L-Dopa decarboxylase (2003), Neurochem. Res., 28, 797-803.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.1.1.28 | cDNA, alternative mRNA splice variants, neuronal and nonneuronal | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.1.1.28 | 0.13 | - |
L-Dopa | pH 8.0, 37°C | Homo sapiens |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.28 | 50000 | - |
2 * 50000, SDS-PAGE | Homo sapiens |
| 4.1.1.28 | 54000 | - |
recombinant enzyme, immunoblotting | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.28 | L-tryptophan | Homo sapiens | - |
tryptamine + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.28 | Homo sapiens | - |
human | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.1.1.28 | recombinant enzyme | Homo sapiens |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.1.1.28 | additional information | - |
specific activity 490 U/mg, enzyme activity is expressed in nanomole of substrate transformed per minute per milliliter of enzyme preparation | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.28 | L-Dopa | - |
Homo sapiens | dopamine + CO2 | - |
? | |
| 4.1.1.28 | L-tryptophan | - |
Homo sapiens | tryptamine + CO2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.28 | homodimer | 2 * 50000, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.28 | Aromatic L-amino acid decarboxylase | - |
Homo sapiens |
| 4.1.1.28 | DDC | - |
Homo sapiens |
| 4.1.1.28 | L-3,4-Dihydroxyphenylalanine decarboxylase | - |
Homo sapiens |
| 4.1.1.28 | L-DOPA decarboxylase | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.28 | pyridoxal 5'-phosphate | - |
Homo sapiens | |
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