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Literature summary extracted from

  • Bell, J.K.; Goetz, D.H.; Mahrus, S.; Harris, J.L.; Fletterick, R.J.; Craik, C.S.
    The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity (2003), Nat. Struct. Biol., 10, 527-534.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.78 cDNA subcloned into the yeast vector pPICzalphaA and heterologously expressed in Pichia pastoris Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.21.78
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.78 N153Q molecular replacement Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.78 additional information ecotin has no effect Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.78 additional information Homo sapiens cell death-inducing serine protease ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.78 Homo sapiens
-
 human
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.78 recombinant enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.78 additional information cell death-inducing serine protease Homo sapiens ?
-
 ?
3.4.21.78 PSSCL + H2O
-
 Homo sapiens Pro-Ser + Ser-Lys-Lys
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.78 dimer only granzyme that forms a disulfide-linked homodimer Homo sapiens
3.4.21.78 oligomer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.78 Gzma
-
 Homo sapiens