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Literature summary extracted from

  • Tomkinson, A.E.; Mackey, Z.B.
    Structure and function of mammalian DNA ligases (1998), Mutat. Res., 407, 1-9.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.5.1.1 100000
-
 1 * 100000 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens
-
 AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Bos taurus
-
 AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Bos taurus
-
-
-
6.5.1.1 Bos taurus
-
 indication, that DNA ligase II from bovine liver is derived from DNA ligase IIIalpha by proteolysis
-
6.5.1.1 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.5.1.1
-
 Homo sapiens
6.5.1.1
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.1 293 cell
-
 Homo sapiens
-
6.5.1.1 HeLa cell
-
 Homo sapiens
-
6.5.1.1 liver
-
 Bos taurus
-
6.5.1.1 testis
-
 Bos taurus
-
6.5.1.1 thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Bos taurus AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m inable to join oligo(dT) molecules hybridized to poly(rA) Bos taurus AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m ligation of oligo(dT)/poly(dA) Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m ligation of oligo(dT)/poly(dA) and oligo(dT)/poly(rA) and oligo(rA)/poly(dT) Bos taurus AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m ligation of oligo(dT)/poly(dA) and oligo(dT)/poly(rA), unable to ligate oligo(rA)/poly(dT) Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m ligation of oligo(dT)/poly(dA) and oligo(dT)/poly(rA), unable to ligate oligo(rA)/poly(dT) Bos taurus AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Subunits

EC Number Subunits Comment Organism
6.5.1.1 monomer 1 * 100000 Bos taurus

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 DNA ligase I
-
 Bos taurus
6.5.1.1 DNA ligase II
-
 Bos taurus
6.5.1.1 DNA ligase III
-
 Bos taurus
6.5.1.1 DNA ligase IV
-
 Homo sapiens
6.5.1.1 DNA ligase V
-
 Homo sapiens