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Literature summary extracted from
- The HtrA family of serine proteases (1997), Mol. Microbiol., 26, 209-221.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | biotechnology | htrA mutants show improved expression of envelope-associated proteins | Escherichia coli |
| 3.4.21.107 | medicine | aroC aroD HtrA mutant shows promise as a typhoid vaccine in humans | Salmonella enterica subsp. enterica serovar Typhimurium |
| 3.4.21.107 | medicine | htrA mutants can act as vaccines | Escherichia coli |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.21.107 | - |
Yersinia enterocolitica |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | H105R | loss of protease activity, no change in secondary structure | Escherichia coli |
| 3.4.21.107 | S210A | loss of protease activity, no change in secondary structure | Escherichia coli |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.107 | inner membrane | periplasmic side of the inner membrane | Escherichia coli | - |
- |
| 3.4.21.107 | periplasm | - |
Escherichia coli | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.107 | Mg2+ | - |
Escherichia coli |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.107 | additional information | Yersinia enterocolitica | deletion mutant is unable to grow at an elevated temperature and to survive within macrophages after phagocytosis | ? | - |
? | |
| 3.4.21.107 | additional information | Escherichia coli | involved in the degradation of misfolded proteins | ? | - |
? | |
| 3.4.21.107 | additional information | Salmonella enterica subsp. enterica serovar Typhimurium | mutants are deficient in their ability to survive in mice or macrophages | ? | - |
? | |
| 3.4.21.107 | Protein + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | - |
? | - |
? | |
| 3.4.21.107 | Protein + H2O | Escherichia coli | - |
? | - |
? | |
| 3.4.21.107 | Protein + H2O | Yersinia enterocolitica | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.107 | Escherichia coli | - |
- |
- |
| 3.4.21.107 | Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
| 3.4.21.107 | Yersinia enterocolitica | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.107 | Arc repressor + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.4.21.107 | beta-casein + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.4.21.107 | colicin A lysis protein precursor + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.4.21.107 | IciA protein + H2O | inhibitor of DNA replication initiation | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | lambda repressor + H2O | N-terminal domain | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | additional information | deletion mutant is unable to grow at an elevated temperature and to survive within macrophages after phagocytosis | Yersinia enterocolitica | ? | - |
? | |
| 3.4.21.107 | additional information | involved in the degradation of misfolded proteins | Escherichia coli | ? | - |
? | |
| 3.4.21.107 | additional information | mutants are deficient in their ability to survive in mice or macrophages | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| 3.4.21.107 | Protein + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
| 3.4.21.107 | Protein + H2O | - |
Escherichia coli | ? | - |
? | |
| 3.4.21.107 | Protein + H2O | - |
Yersinia enterocolitica | ? | - |
? | |
| 3.4.21.107 | Protein + H2O | denatured proteins aggregate to form a distinct S fraction, one third of the isolated S fraction is converted to trichloroacetic acid-soluble products, enzyme has a preference for valine or isoleucine as the residue preceding the cleavage site | Escherichia coli | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | oligomer | largest complexes are dodecamers, probably formed by dimerization of trimers, gel filtration experiments | Escherichia coli |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.107 | DegP | - |
Escherichia coli |
| 3.4.21.107 | Do protease | - |
Escherichia coli |
| 3.4.21.107 | HtrA | - |
Escherichia coli |
| 3.4.21.107 | HtrA2 | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
| 3.4.21.107 | HtrA2 | - |
Yersinia enterocolitica |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.107 | 55 | - |
- |
Escherichia coli |
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