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Literature summary extracted from

  • McCulloch, D.R.; Harvey, M.; Herington, A.C.
    The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone (2000), Mol. Cell. Endocrinol., 167, 11-21.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.B9 stanolone upregulation, 1.5fold increase in activity at 0.000001 mM, 1.7fold at 0.00001 mM Homo sapiens
3.4.24.B10 stanolone regulation in a bell-shaped, dose-dependent manner, maximal, 5fold increase in activity at 0.000001 mM Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.B9 membrane
-
 Homo sapiens 16020
-
3.4.24.B10 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.B9 proteins + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.B10 protein + H2O Homo sapiens
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.B9 Homo sapiens
-
-
-
3.4.24.B10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.B9 ALVA-41 cell androgen-dependent prostate cancer cell line Homo sapiens
-
3.4.24.B9 DU-145 cell androgen-independent prostate cancer cell line Homo sapiens
-
3.4.24.B9 LNCaP cell androgen-dependent prostate cancer cell line Homo sapiens
-
3.4.24.B9 PC-3 cell androgen-independent prostate cancer cell line Homo sapiens
-
3.4.24.B9 prostate cancer cell cell culture Homo sapiens
-
3.4.24.B10 ALVA-41 cell androgen-dependent prostate cancer cell line Homo sapiens
-
3.4.24.B10 DU-145 cell androgen-independent prostate cancer cell line Homo sapiens
-
3.4.24.B10 LNCaP cell androgen-dependent prostate cancer cell line Homo sapiens
-
3.4.24.B10 PC-3 cell androgen-independent prostate cancer cell line Homo sapiens
-
3.4.24.B10 prostate cancer cell cell culture Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.B9 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B10 protein + H2O
-
 Homo sapiens peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.B9 a disintegrin and metalloproteinase domain 9
-
 Homo sapiens
3.4.24.B9 ADAM9
-
 Homo sapiens
3.4.24.B9 M12.209 Merops-ID Homo sapiens
3.4.24.B10 a disintegrin and metalloproteinase domain 12
-
 Homo sapiens
3.4.24.B10 ADAM12
-
 Homo sapiens
3.4.24.B10 M12.212 Merops-ID Homo sapiens