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Literature summary extracted from

  • Huang, Y.; Zhang, X.Y.; Liu, F.; Chen, H.L.
    Regulation of phospholipase D from human hepatocarcinoma cell line by purine nucleotides and protein kinase A (2000), Mol. Cell. Biochem., 207, 3-8.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 ADP at 1 mM, 200% of control activity Homo sapiens
3.1.4.4 ATP at 1 mM, 320% of control activity, 1 mM ATP + 0.1 mM GTP, 720% of control activity, effect is abolished by neomycin Homo sapiens
3.1.4.4 cAMP at 1 mM, 273% of control activity Homo sapiens
3.1.4.4 GDP at 1 mM, 312% of control activity Homo sapiens
3.1.4.4 GTP at 0.1 mM, 273% of control activity, 1 mM ATP + 0.1 mM GTP, 720% of control activity, effect is abolished by neomycin Homo sapiens
3.1.4.4 GTPgammaS at 0.005 mM, 446% of control activity Homo sapiens
3.1.4.4 additional information not activating: AMP Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 neomycin abolishes activation by GTP or ATP Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 liver hepatocarcinoma cell culture Homo sapiens
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