EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.17 | adenosine | approx. 10fold activation of dephosphorylated ODC at 1 mM, approx. 2fold activation of native ODC | Thermus thermophilus | |
4.1.1.17 | ATP | approx. 10fold activation of dephosphorylated ODC at 1 mM, approx. 1.5fold activation of native ODC | Thermus thermophilus | |
4.1.1.17 | GMP | approx. 10fold activation of dephosphorylated ODC at 1 mM, approx. 1.2fold activation of native ODC | Thermus thermophilus | |
4.1.1.17 | GTP | approx. 10fold activation of dephosphorylated ODC at 1 mM, approx. 2.5fold activation of native ODC | Thermus thermophilus | |
4.1.1.17 | phosphoserine | 2 mM, 1.5fold activation | Thermus thermophilus | |
4.1.1.17 | spermidine | 2 mM, 40% activation | Thermus thermophilus | |
4.1.1.17 | spermine | 2 mM, 140% activation | Thermus thermophilus | |
4.1.1.17 | UTP | approx. 10fold activation of dephosphorylated ODC at 1 mM, approx. 2fold activation of native ODC | Thermus thermophilus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.17 | antizyme | non-competitive inhibitor protein isolated from Thermus thermophilus or Escherichia coli, almost complete inhibition at higer concentrations | Escherichia coli | |
4.1.1.17 | antizyme | non-competitive inhibitor protein isolated from Thermus thermophilus | Thermus thermophilus | |
4.1.1.17 | L-arginine | competitive inhibition | Thermus thermophilus | |
4.1.1.17 | L-lysine | competitive inhibition | Thermus thermophilus | |
4.1.1.17 | putrescine | slight inhibition | Thermus thermophilus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.17 | 0.5 | - |
L-ornithine | - |
Thermus thermophilus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
4.1.1.17 | 68000 | - |
2 * 68000, SDS-PAGE | Thermus thermophilus |
4.1.1.17 | 135000 | - |
gel filtration | Thermus thermophilus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.17 | L-ornithine | Escherichia coli | - |
putrescine + CO2 | - |
? | |
4.1.1.17 | L-ornithine | Thermus thermophilus | involved in polyamine biosynthesis | putrescine + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.17 | Escherichia coli | - |
- |
- |
4.1.1.17 | Thermus thermophilus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
4.1.1.17 | phosphoprotein | inactive after incubation with alkaline phosphatase | Thermus thermophilus |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.1.1.17 | - |
Escherichia coli |
4.1.1.17 | ammonium sulfate, DEAE-Biogel A, heparin-Sepharose, Sephadex G 150, Phenyl-Sepharose, Lysine-Sepharose, pyridoxamine-affi gel | Thermus thermophilus |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
4.1.1.17 | 0.078 | - |
- |
Thermus thermophilus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.17 | L-ornithine | - |
Thermus thermophilus | putrescine + CO2 | - |
? | |
4.1.1.17 | L-ornithine | - |
Escherichia coli | putrescine + CO2 | - |
? | |
4.1.1.17 | L-ornithine | involved in polyamine biosynthesis | Thermus thermophilus | putrescine + CO2 | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
4.1.1.17 | dimer | 2 * 68000, SDS-PAGE | Thermus thermophilus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.17 | ODC | - |
Thermus thermophilus |
4.1.1.17 | ODC | - |
Escherichia coli |
EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.1.1.17 | 70 | 85 | 85% loss of activity after 15 min at 75°C, more than 95% loss of activity after 15 min at 85°C and above | Thermus thermophilus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.1.1.17 | 7.5 | - |
- |
Thermus thermophilus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.17 | pyridoxal 5'-phosphate | - |
Thermus thermophilus |