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Literature summary extracted from

  • Reynolds, P.E.; Ambur, O.H.; Casadewall, B.; Courvalin, P.
    The VanY(D) DD-carboxypeptidase of Enterococcus faecium BM4339 is a penicillin-binding protein (2001), Microbiology, 147, 2571-2578.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.16.4 benzylpenicillin IC50: 0.00002 mg/ml, inhibition of the enzyme influences production of peptidoglycan precursors internally Enterococcus faecium

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.16.4 membrane membrane-bound, the active site is present on the outside surface of the membrane Enterococcus faecium 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.16.4 UDP-MurNAc-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala + H2O Enterococcus faecium
-
 UDP-MurNAc-L-Ala-D-Glu-L-Lys-D-Ala + D-Ala
-
 ?
3.4.16.4 UDP-MurNAc-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala + H2O Enterococcus faecium BM4339
-
 UDP-MurNAc-L-Ala-D-Glu-L-Lys-D-Ala + D-Ala
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.16.4 Enterococcus faecium
-
 BM4339
-
3.4.16.4 Enterococcus faecium BM4339
-
 BM4339
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.16.4 additional information penicillin-binding protein Enterococcus faecium ?
-
 ?
3.4.16.4 additional information penicillin-binding protein Enterococcus faecium BM4339 ?
-
 ?
3.4.16.4 UDP-MurNAc-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala + H2O
-
 Enterococcus faecium UDP-MurNAc-L-Ala-D-Glu-L-Lys-D-Ala + D-Ala
-
 ?
3.4.16.4 UDP-MurNAc-L-Ala-D-Glu-L-Lys-D-Ala-D-Ala + H2O
-
 Enterococcus faecium BM4339 UDP-MurNAc-L-Ala-D-Glu-L-Lys-D-Ala + D-Ala
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.16.4 VanY(D) DD-carboxypeptidase
-
 Enterococcus faecium
3.4.16.4 VanYD
-
 Enterococcus faecium