Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cen, S.; Khorchid, A.; Javanbakht, H.; Gabor, J.; Stello, T.; Shiba, K.; Musier-Forsyth, K.; Kleiman, L.
    Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1 (2001), J. Virol., 75, 5043-5048.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.1.1.6 cytoplasm cytoplasmic isozyme Homo sapiens 5737
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.1.1.6 62000 63000 isozyme packaged into virions, proteolytically truncated, gel filtration Homo sapiens
6.1.1.6 70000
-
 cytoplasmic isozyme, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.6 ATP + L-lysine + tRNALys Homo sapiens
-
 AMP + L-lysyl-tRNALys + diphosphate
-
 ?
6.1.1.6 additional information Homo sapiens enzyme is selectively packaged into virions during assembly of the human immunodeficiency virus type 1, i.e. HIV-1, through interaction with the viral Pr55gag protein, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.6 Homo sapiens
-
 overexpressed and purified His-tagged enzyme from Escherichia coli
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
6.1.1.6 proteolytic modification prior of packing of the enzyme into viral particles, it is truncated independent of viral protease Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.6 ATP + L-lysine + tRNALys
-
 Homo sapiens AMP + L-lysyl-tRNALys + diphosphate
-
 ?
6.1.1.6 additional information enzyme is selectively packaged into virions during assembly of the human immunodeficiency virus type 1, i.e. HIV-1, through interaction with the viral Pr55gag protein, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.1.1.6 L-Lysine-transfer RNA ligase
-
 Homo sapiens
6.1.1.6 Lysine translase
-
 Homo sapiens
6.1.1.6 Lysine--tRNA ligase
-
 Homo sapiens
6.1.1.6 Lysine-tRNA synthetase
-
 Homo sapiens
6.1.1.6 LysRS
-
 Homo sapiens
6.1.1.6 Lysyl-transfer ribonucleate synthetase
-
 Homo sapiens
6.1.1.6 Lysyl-transfer RNA synthetase
-
 Homo sapiens
6.1.1.6 Lysyl-tRNA synthetase
-
 Homo sapiens
6.1.1.6 Synthetase, lysyl-transfer ribonucleate
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.6 ATP
-
 Homo sapiens