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Literature summary extracted from

  • Li, Y.; Spencer, F.A.; Ball, S.; Becker, R.C.
    Inhibition of platelet-dependent prothrombinase activity and thrombin generation by glycoprotein IIb/IIIa receptor-directed antagonists: potential contributing mechanism of benefit in acute coronary syndromes (2000), J. Thromb. Thrombolysis, 10, 69-76.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.6 medicine glycoprotein IIb/IIIa receptor antagonists in combination with heparin might contribute to improved therapy of acute coronary syndromes abd during percutaneous coronary interventions Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.6 abciximab glycoprotein IIb/IIIa receptor-antagonist, 3.8% inhibition at 0.140 mM in absence of heparin, 49% inhibition at 0.14 mM in presence of heparin 1 U/ml Homo sapiens
3.4.21.6 enoxaparin increases the inhibitory effect of abciximab and eptifibatide Homo sapiens
3.4.21.6 eptifibatide glycoprotein IIb/IIIa receptor-antagonist, 13.5% inhibition at 0.333 mM in absence of heparin, 38% inhibition at 0.14 mM in presence of heparin 1 U/ml Homo sapiens
3.4.21.6 heparin highly increases the inhibitory effects of glycoprotein IIb/IIIa receptor-antagonists Homo sapiens
3.4.21.6 tirofiban glycoprotein IIb/IIIa receptor-antagonist, 16.9% inhibition at 0.042 mM in absence of heparin, 48% inhibition at 0.14 mM in presence of heparin 1 U/ml Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.6 prothrombin + H2O Homo sapiens
-
 thrombin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.6 Homo sapiens
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.6 selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.6 blood
-
 Homo sapiens
-
3.4.21.6 plasma
-
 Homo sapiens
-
3.4.21.6 platelet
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.6 prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.6 More factor Xa is part of the prothrombinase complex with Ca2+, phospholipids and factor Va Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.6 More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens
3.4.21.6 prothrombinase
-
 Homo sapiens