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Literature summary extracted from

  • Kekenes-Huskey, P.M.; Vaidehi, N.; Floriano, W.B.; Goddard, W.A.
    Fidelity of Phenylalanyl-tRNA Synthetase in Binding the Natural Amino Acids (2003), J. Phys. Chem. B, 107, 11549-11557.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.1.1.20 additional information
-
 additional information kinetics, binding energies in the active conformation Thermus thermophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.1.1.20 ATP + L-phenylalanine + tRNAPhe Thermus thermophilus
-
 AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 r

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.20 Thermus thermophilus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
6.1.1.20 ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe substrate binding mechanism, residues S180, Q218, E220, W149, H178, R204, and Q218 are involved in binding of phenylalanine via hydrogen bonds Thermus thermophilus
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.20 ATP + L-phenylalanine + tRNAPhe
-
 Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 r
6.1.1.20 ATP + L-phenylalanine + tRNAPhe reaction intermediate aminacyl-AMP stucture Thermus thermophilus AMP + diphosphate + L-phenylalanyl-tRNAPhe
-
 r

Synonyms

EC Number Synonyms Comment Organism
6.1.1.20 CML33
-
 Thermus thermophilus
6.1.1.20 FRS
-
 Thermus thermophilus
6.1.1.20 HSPC173
-
 Thermus thermophilus
6.1.1.20 L-Phenylalanyl-tRNA synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanine translase
-
 Thermus thermophilus
6.1.1.20 Phenylalanine--tRNA ligase
-
 Thermus thermophilus
6.1.1.20 Phenylalanine-tRNA synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl transfer ribonucleic acid synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-transfer ribonucleate synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-transfer RNA ligase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-transfer RNA synthetase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-tRNA ligase
-
 Thermus thermophilus
6.1.1.20 Phenylalanyl-tRNA synthetase
-
 Thermus thermophilus
6.1.1.20 PheRS
-
 Thermus thermophilus
6.1.1.20 Synthetase, phenylalanyl-transfer ribonucleate
-
 Thermus thermophilus

Cofactor

EC Number Cofactor Comment Organism Structure
6.1.1.20 ATP
-
 Thermus thermophilus